Don’t let your pressure research drift: new solid-state wireless catheter

ADInstruments is pleased to offer our customers the Millar Instruments enabled, fully-implantable, solid-state wireless pressure catheter by Telemetry Research.

Measuring just 2 Fr (0.66 mm), the MLE1024 TR/Millar Pressure Transmitter (non-repairable) catheter is configured for extremely low offset drift and a frequency response of 450 Hz. The MLE1024 transmitter is 7 cc, the smallest produced to date. It can be used to measure intravascular or intralumenal pressure and temperature in small animals 200 g or larger (ideal for rats). 

The MLE1024 TR/Millar Pressure Transmitter unit

Data from multiple MLE1024 units can be wirelessly collected by the MLE1151 TR/Millar Master Receiver Controller and MLE1151SUB TR/Millar Pressure Subsidiary Receiver; up to 12 transmitters can be detected within a 5-meter range. For continuous recording, MLE1024 transmitter batteries can be recharged in vivo, with the MLE1005CPS Wireless Continuous Power Supplier. The MLE1024 is functional with these receiver and recharger devices only.

Solid-state catheter

Typical issues encountered when using a fluid-filled catheter can be signal distortion, signal attenuation and signal loss, which are related to gravity, subject movement and occlusion of the catheter with blood clots. The MLE1024 removes these risks, as it has a solid-state sensor. The sensor is located at the tip of the catheter and does not require fluid or regelling.

The MLE1024 can be implanted almost anywhere in a small subject (weighing at least 200 g), and still provide a stable and accurate signal that is not impacted by gravity or rapid movements (such as scratching or running). The transmitter has a rigid biocompatible plastic casing, with rear suture apertures for ease of implantation. Because it is easily cleaned with enzymatic detergent, the MLE1024 can be used up to 100 times by careful and experienced researchers. 

Side view of MLE1024 rear suture apertures	The MLE1024 catheter tip next to a paperclip

Low offset drift

The MLE1024 is configured to give extremely low baseline drift, even with deep implantation. All catheter transmitters are calibrated before shipment: 0mmHg equals an analog output voltage of 1 V, and 100 mmHg equals 2 V. The drift specification is <2 mmHg per month.  Researchers can easily check the offset value between uses, however it is imperative to replicate the conditions of calibration, namely: the sensor is clean and hydrated for 48 hrs, is in the dark and held at 37 °C. 

Close-up of the MLE1024 sensor

Frequency response

The MLE1024 offers high fidelity for the sensing of pressure, with a 3 dB frequency response of 450 Hz and sampling frequency of 2000 Hz.  The high resolution and accuracy makes the MLE1024 ideal for studies that measure fast events (such as dP/dT).

The frequency response of MLE1024 vs. a traditional fluid filled catheter telemetry system. 
Data and image provided by Telemetry Research.

LabChart, showing blood pressure data acquired with the MLE1024 TR/Millar Pressure Transmitter.
Channel 1:  Blood pressure (mmHg); Channel 2:  Temperature (°C); Channel 3:  Heart rate (BPM).

Complete Research System

A research foundation system [ML880B108 Telemetry Blood Pressure Foundation System (Millar) is also available to use ONLY with the MLE1024 (purchased separately).
 

This system includes: 1x ML880 16 channel PowerLab with LabChart and Scope software 1x MLS260 LabChart Pro software 1x ML319 TR Scheduler Pod 1x MLE1151 TR/Millar Pressure Master Receiver 1x MLE1005CPS Wireless Continuous Power Supplier 2x MLAC01 BNC-BNC Cables The MLE1024 transmitter is not included in this system.

MLE1005CPS wireless continuous power supplier

 Accessories

The MLE1145 TR/Millar Consumable Pack includes the MLE1024 unit and consumables required for one surgical training session (excluding surgical instruments).

The pack includes:

• 1x MLE1024 TR/Millar Pressure Transmitter
• Surgical training DVD
• Tissue adhesive
• 4x Catheter introducers
• 2 Meters of 4.0 suture material
• Needles, swabs, swab sticks, absorbent surgical spears, skin stapler and surgical mesh

All surgical items are supplied non-sterile.

More Information:   More about Telemetry  Contact your local representative   Download the Telemetry brochure (.pdf)

10 May 2010