Radnoti Single Chamber Organ Bath

Overview:

The 159911-X1 Radnoti Single Chamber Organ Bath is a high quality bath ideal for conducting physiological measurements on a single tissue or organ sample in teaching or research applications.

It is supplied with a 25 mL High Tech tissue bath, which is individually mounted via an adjustable ring-clamp to a stainless steel support rod that is anchored to a sturdy steel base. The base is coated to resist corrosive salt solutions. Tissue and transducer holders, micropositioner are also supplied.

The perfusate flows from a water jacketed, temperature controlled 1-liter reservoir then enters the tissue bath through a pre-heating coil built within the water jacket of tissue baths. The baths is emptied via a bottom drain that is controlled by a stopcock. The bath may also be used in a constant flow mode with the excess perfusate exiting an overflow outlet at the top of the bath. Both overflow and drain may be routed to permit monitoring the release of endogenous substances, drug metabolites, or to design a cascade system configuration. Gas regulation is finely controlled via a removable Teflon needle valve inserted at the side of the chamber.

ADInstruments can supply a suitable isometric or isotonic Force Transducer. To maintain a constant temperature in the tissue chamber, the MLE2001 Thermoregulated Water Pump is available.

Features:

• Modular in design allows easy customization
• Coated steel base is resistance to corrosive salt solutions
• Water jacketed glassware provide constant temperature maintenance
• High-Tech tissue bath design provides constant flow mode with the waste perfusate exiting an overflow outlet at the top of the bath
• Gas regulation is finely controlled via a removable Teflon needle valve Oxy-tube

Applications:

Radnoti Organ Baths are used for in vitro dose response experiments, used extensively to investigate the physiology and pharmacology of tissue preparations from various species (chick, toad, rabbit, rat, guinea-pig, etc.) Some of the tissues that may be studied with an organ bath system include:

Smooth Muscle:

• Vascular, e.g. arterial/aortic rings
• Guinea-pig ileum
• Vas Deferens (secretory duct of the testicle)
• Uterine
• Colon

Skeletal Muscle:

• Toad Abdominus Rectus
• Chick Biventer Cervis
• Mammalian Diaphragm

For more information visit the Organ Bath Experiments application page.
 

Specifications: