Multi Chamber Myograph w/Touch Screen

Overview:

The DMT620M Multi Chamber Myograph w/Touch Screen is ideal for multiple testing of vessel reactivity with the chambers (8 ml volume) arranged conveniently side by side in a single unit. It is ideal for work requiring high throughput such as drug screening. Each chamber of the DMT620M features needle valves for individual control of chamber oxygenation, automatic time control of chamber suction and selectable force ranges. The unit comes with wire jaws, for tissues greater than 60 µm diameter. The DMT620M also comes with pins which are used for studies involving larger vessels or tubular structures of diameters up to 10 mm.

The DMT620M comes with a built-in control unit with temperature control, built-in high-resolution force transducers and micrometers. The unit has analog outputs which can be connected directly to PowerLab BNC inputs. The Multi Chamber Myograph w/Touch Screen System is also available and includes a PowerLab data acquisition system, LabChart Pro and DMT620M.

When purchasing the DMT620M the following items are included:

Multi-Chamber Myograph Unit

• 1 power cord (The shape of the AC plug varies by country; be sure that the plug has the right shape for your location)
• 4 chamber units with mounted stainless steel jaws
• 4 set of mounting support pins
• 4 chamber covers
• 1 external temperature probe
• 1 Calibration kit (including bridge, balance and 2 gram weight)

Accessories

• 4 plastic funnels
• 1 roll of 40 μm stainless steel wire
• 1 tube of high vacuum grease
• 1 tube of grease for linear slides
• 4 spare screws for mounting of jaws
• 2 Allen keys
• 1 small screwdriver

Manuals

• 1 User manual
• 1 manual by Professor M. J. Mulvany - “Procedures for Investigation of Small Vessels using small vessel myograph”

Warranty Exclusion

• DMT force and pressure transducers, either separately or part of myograph systems manufactured by DMT A/S, are disclaimed from any warranty

The DMT100192 Automated Buffer Filler System 2 (625FS), which can be additionally purchased, is an optional add-on to any 4-chanel myographs that provides an automatic, reliable and consistent way to replace buffer in the bath chambers.

Features:

• Chamber volume of up to 10ml
• Chamber cover includes a port for filling and injection of drugs
• Chamber includes ports for rapid draining (NOTE: a vacuum pump is required for drainage, not supplied with systems)
• Chamber includes ports for gas supply
• Acid-resistant, stainless steel chamber to facilitate cleaning
• Metal mounting heads
• Can be mounted with tubular structures from a diameter > 60 μm
• All myographs are heated, maintaining temperatures to the nearest 0.1°C
• Micrometers with a range of 7 mm and a resolution of 10 μm
• Myo-interface unit which contains all the commands and setup menus for use with the myograph unit

Applications:

The DMT620M Multi Chamber Myograph w/Touch Screen is ideal for multiple testing of vessel reactivity and high throughput such as drug screening. DMT wire myographs, whilst predominantly used for investigations using arterial microvessels, can be easily used on a variety of other tissue types such as small veins, renal arcuate arteries, bronchi and ureter. The technique, is suited to vessels with internal diameters > 60 μm.

Parameters which can be measured include:

• Normalized internal diameter
• Measuring tissue wall thickness
• Isometric (force) responses to drugs (agonists/antagonists)
• Simultaneous measurements of isometric response and cell membrane potential
• Simultaneous measurements of isometric responses and ion concentrations inside the cell
• Analysis of tissue fixed under clearly defined conditions for microscope measurements

For more information see the Wire Myography application page.

Specifications: