Extracellular Preamplifier

Overview:

The 2400A is a versatile low-noise preamplifier with high gain, active filters and an audio amplification and neutralized input capacitance which provides fast rise times. The instrument provides the ability to inject current and voltage through the microelectrode using several methods. This preamplifier is ideal for any extracellular recordings.The preamplifier integrates seamlessly via the BNC analog outputs with PowerLab data acquisition systems.

The preamplifier is supplied with a Capacitance Compensation Probe.

Extracellular recordings can be analyzed using the Spike Histogram software module, which is available for Windows and Mac OS.

Note: DC/Battery optional Input Jacks can be installed at the time of purchase for an extra US$105. To order the amplifier with these jacks please quote the following Product Number 2400A/DC.

PLEASE NOTE: This equipment is not intended for use in human applications or human experimentation.

Features:

• Low noise
• Built-in audio monitor amplifier
• Ability to inject current and voltage through the microelectrode by several different methods
• Neutralized input capacitance which allows fast rise time signals to be viewed with high microelectrode resistance's
• Very high voltage gain of the preamplifier section  (switch selection of: 50, 100, 200, 500, 1000, 2000, 5000, or 10,000) no additional amplification needed between the microelectrode and the recording instrumentation
• Preamplifier designed to be used with both high and low impedance electrodes  
  
• A CALIBRATE switch which allows a precise signal to be passed form the preamplifier to calibrate recording or viewing instrumentation 
• The CURRENT PUMP provides a precisely regulated Current from 0to plus or minus 1000 nA for injection of dyes or drugs from the microelectrode by iontophoresis

Applications:

This Extracellular Preamplifier is ideal for any extracellular recordings of voltage and current changes outside of a cell from nerve fibers to brain slices.

See our Extracellular Recordings application page for more information.

Specifications:

PREAMPLIFIER

• IMPEADANCE (Z) TEST: 100mV/megohm 

• NEUTRALIZATION: 15 turn control located on probe.Range is 0 to100 pF. 

• INPUT IMPEDANCE: Greater than 10,000 Megohms 

• INPUT CONNECTOR: Min. co-ax 

• OUTPUT: 10 ohms, 20 volt peak to peak, BNC connector 

• GAIN: 50, 100, 200 500, 1K, 2K, 5K, 10K 

• OVERLOAD RECOVERY: Recovery is very fast, usually one-half to a few milliseconds except for just after Stain, recovery is then 20 to 40seconds. 

• NOISE: Due to Amplifier and Source Resistance (takes into account current and voltage noise), RMS and Peak to Peak (P-P) 

Bandwidth	Source Resistance
	100Kohm	1 Megohm	10 Megohm
1 Hz to1 K Hz	1.6 uV RMS	4.5 uV RMS	16 uV RMS
	8 uVP-P	22 uV P-P	80 uV P-P
1 Hz to 10 KHz	4.5 uV RMS	12 uV RMS	40 uV RMS
	22 uVP-P	60 uV P-P	200 uV P-P

• CALIBRATE GENERATOR: 100 mV @ 1%, Peak to Peak Square Wave, 150Hz 

• LINE NOTCH FILTER: Standard 60 Hz, (optional 50Hz.)The Rejection ratio is 200 to 1 or 46 dB. 

• HIGH FREQUENCY FILTER: Activate 20dB/decade,push button switch selection3 dB points are; 100, 300, 1000, 3K, 1OK, 30K, and 100KHz. 

• LOW FREQUENCY FILTER: Active 20 dB/decade, Push button switch selection3 dB points are; 0.3, 1.0, 3.0, 10, 30, 100, and 300 Hz 

• AUDIO MONITOR: An internal audio power amplifier monitors the Preamplifier Output. Sound level is controlled by the Monitor control. Output is through two Binding Posts located on rear panel, An 8 ohm speaker is recommended.

CURRENT PUMP

• PUMP LEVEL:EXTERNAL: An analog voltage betweenminus10 to plus10 volts into the rear panel BNC jack generates a current between minus1000 nA, to plus 1000 nA. INTERNAL: The INTERNAL position enables the20turn digital dial current setting. The dial is read out in nA, and has a range of 0 to 1000 nA. Polarity is determined by the PUMP POLARITY Switch. 
• STAIN: A POSITIVE (for metal electrodes) Or NEGATIVE (for Glass electrodes) voltage of 15 volts limited by 10,000 ohms is fed into the electrode. 
• ELECTRODE (PROBE MODE): A four station push button switch selects the mode of operation by connecting the probe input connector to the four functions via a reed relay located in the probe. The Four functions are: 
• CURRENT PUMP: The CURRENT PUMP section of the instrument is connected through the probe to the electrode. The CURRENT PUMP is always available through the AUX PUMP OUT BNC jack. 
• PREAMPLIFIER: The probe and audio monitor amplifier are connected to the electrode. 
• EXTERNAL: The electrode is connected to the EXTERNAL BNC jack. This position gives direct access to the electrode for passage of any voltage or current 
• STAIN: The high level STAIN current is fed to the microelectrode  

GENERAL

• POWER: 115v AC, 60 Hz, 6 Watts (optional 230v AC,50Hz, 4 Watts) 
• DIMENSIONS: 

• WEIGHT: 5 K gr.(11 pounds)