NIBP System (for Rats)

Overview:

The ML125/R NIBP System is used in conjunction with a PowerLab system to obtain non-invasive blood pressure measurement from rats (with tail diameters 5-10 mm). It uses a specialized tail cuff and pulse transducer to intermittently measure blood pressure based on the periodic occlusion of tail blood flow.

The ML125/R system comes with a tail cuff and pulse transducer suitable for rats. The NIBP System outputs the pressure and pulse signals to a PowerLab via a BNC connection. LabChart software can be used to start the NIBP Controller at pre-set times. This is useful when the pulse is recorded continuously but blood pressure only needs to be sampled periodically.

The ML125/R NIBP System for rats includes a ML125 NIBP Controller and MLT125/R Pulse Transducer/Pressure Cuff for NIBP (Rat).
 
Suitable rat restrainers are available separately:

• MLA5020 Rodent Restrainer (80 to 200 g)
• MLA5022 Rodent Restrainer (180 to 320 g)
• MLA5024 Rodent Restrainer (300 to 440 g)
• MLA5025 Rodent Restrainer (440 to 550 g)

For a tail cuff system suitable for mice (with tail diameters 3- 6 mm), see the ML125/M page.

A MLA5030 Rodent Tail Cuff Holder, which allows the user to secure the rat tail transducer and cuff (MLT125/R) when attached to a rat tail, is also available separately.

Hardware:
The NIBP will only function with PowerLab data acquisition units and therefore is not suitable for use with other data acquisition systems.

Features:

Applications:

The NIBP System is used in conjunction with a PowerLab system to obtain non-invasive blood pressure measurement from rats (with tail diameters <10 mm).

This system operates by occluding blood flow to the tail using a specialized tail cuff and pulse transducer to intermittently measure blood pressure based on them periodic occlusion of tail blood flow.

For more information about this application see the Blood Pressure- Non Invasive page.

Specifications:

Cycle Operation

• Max Inflation Pressure: 200 or 280 mmHg (switch-selectable)
• Measurement Cycle Time:

• Cycle Control: Microprocessor based. Performs inflation, deflation, and fast deflation sequences automatically.
  
• Operation Indication: Trigger output (normally low, but high during inflation and deflation cycle). Front panel Status indicator shows inflation and deflation operation.
• Operation Abort: The cycle can be terminated at any point by pressing the front panel Start/Stop button again. Pressure is automatically released.
• Fast Release Time:

• Control Sources: Front panel push button; External signal source (voltage level); Remote contact closure.

Manual Start/Stop Input

• Operation:Contact the closure input for starting or stopping measurement cycle.Shorting the input signal results in a start or stop operation.

Remote Trigger Input

• Operation: Voltage level input for starting or stopping NIBP cycle. TTL compatible input. High level operates a start/stop.
• Input Voltage: 3–5 V
• Minimum Trigger Pulse: 1 ms

Trigger Output

• Operation: High (+5V) output level during measurement cycle. Otherwise zero.

Pressure Output (Cuff Pressure)

• Sensitivity: 0–1 V : 0–300 mmHg (factory calibrated)
• Frequency Response: DC to 10 Hz

Pulse Input

• Input Impedance: Differential Input: 10 GΩ
• Single-ended Input: 1 MΩ
• Input Signal Range: High gain differential input: (0–25 μV) up to (0–75 μV), depending on rear panel Gain Adj setting.
  
• Low gain single-ended input: (0–50 mV) up to (0–150 mV), depending on rear panel Gain Adj setting.
• Bandwidth:

• Pulse Output Max: ± 5 V

Operating Requirements

• Power Requirements: PowerLab or MacLab I²C interface: +9 V @ 100 mA ±18 V @ 50 mA
• Operating Conditions: 5–35 °C, 0–90% humidity (non condensing)

Physical Configuration

• Dimensions (h × w × d): 65 mm × 200 mm × 275 mm (2.56" × 7.9" × 10.8")
• Weight: 1.7 kg

ADInstruments reserves the right to alter these specifications at any time.