The MPVS-300 Foundation Pressure-Volume System is configured for measurement of left ventricular pressure (LVP) and volume in a rat or mouse heart. A variety of Pressure-Volume catheters are available, for assistance please contact your nearest ADInstruments representative. All catheters have pressure sensors (single or double) and electrodes allowing the sensors to be directly placed into the left ventricle of the heart for simultaneous measurement of pressure and volume. The catheters can be used in either closed or open-chest, in vivo as well as in isolated working heart preparations.
The system includes a PowerLab, Pressure-Volume Unit, LabChart and PVAN acquisition and analysis software in the measurement of cardiac function in small animals.
Please Note:
This unit is only suitable for use in small animals and requires Pressure-Volume Catheters to be purchased separately. For more information or assistance please contact your nearest ADInstruments representative.
Advantages in using Millar Pressure-Volume catheters:
- Very little set-up and maintenance required – no fluid-filled catheters to prepare or maintain during experimentation.
- High frequency response – accurately detects and represents signals of varying frequencies without loss of data information.
- Signal integrity – the true waveform is represented with no distortion at high signal frequencies.
- No signal artifacts – no dampening of signals due to air bubbles, or blockages in the catheter.
- Sensor positioned at the tip – detection of signal at the signal source.
- Pressure and volume are measured using a single catheter.
System Components:
Available as a separate item, is a Pressure Gauge kit which provides the necessary items to calibrate the pressure transducer.
The 8-channel PowerLab 8/30 data acquisition system provides the ability to record LVP and volume along as well as the opportunity to simultaneously measure other physiological parameters such as temperature and ECG with the appropriate Signal Conditioners and Transducers.
The MPVS-300 Pressure-Volume Unit provides three analog outputs, two pressure and one volume channel, for measuring LVP and volume signals and connecting to PowerLab. The combined pressure and volume signals can be plotted to generate pressure-volume loops which are used to determine cardiac function.
LabChart allows the simultaneous recording and display of up to 16 channels of data online or offline. These may include left ventricular pressure, left ventricular volume, heart rate, rate of pressure change (dP/dt), rate of volume change (dV/dt), systolic and end-diastolic pressure. Signals, including pressure-volume plots, can be displayed and calculated online whilst recording. Recording channels can be easily calibrated into meaningful units such as mmHg. LabChart data files can be easily imported into PVAN software for additional offline analysis. The PVAN software provides the ability to calculate many specific hemodynamic parameters.
The complete Pressure-Volume system provides the essential tools for the assessment of cardiovascular performance in a number of applications including; phenotyping gene manipulations, cardiac hypertrophy, cardiac failure, cardiovascular remodeling, pharmacology/toxicology and vascular occlusions in small animals.
Some of the parameters which can be calculated using PVAN include:
- Heart rate
- Maximum and minimum volume
- End-systolic volume
- End-diastolic volume
- Maximum and minimum pressure
- End-systolic pressure
- End-diastolic pressure
- Arterial elastance
- Cardiac output
- Stroke work
- Stroke volume
- Ejection fraction
- Maximum and minimum dP/dt
- Maximum and minimum dV/dt
- Pressure at dP/dt Max and dV/dt Max
- Volume at dP/dt Max and dP/dt Min ……and many more
Data Acquisition and Analysis:
The PowerLab 8/30 is shipped with ADInstruments software (
LabChart and
Scope), associated manuals and cables. The ML870/P is also supplied with
LabChart Pro software which includes all the ADInstruments LabChart Modules (excluding GLP). LabChart Modules provide application specific data acquisition, analysis and display features.
The modules currently available include:
In purchasing this system containing LabChart Pro entitles the purchaser to 5 years of FREE LabChart Pro software upgrades and updates. Purchasers are also entitled to any ADInstruments modules released during this 5 year period (excludes GLP software).
For more information see the LabChart Pro page or contact your nearest ADInstruments representative.