Dose Response Module for Windows
- Model# MLS390/7
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Overview:
The MLS390/7 Dose Response Module for LabChart (Windows) allows for the calculation of dose response type data from LabChart recordings. Analysis can be performed automatically or manually and either in real time or offline. Previously recorded LabChart data can be converted for use in the Dose Response Module. The results of the analysis can be exported for use by other applications.
The Dose Response Module identifies response markers in the LabChart recording and uses the selected data to generate dose response curves and calculated values such as EC50 and Hill slopes.
The Dose Response Module should be used with the latest version of LabChart.
The Dose Response Module is also available as part of LabChart Pro. The LabChart Pro software package includes all LabChart Modules. Existing LabChart users and PowerLab system purchasers can upgrade to LabChart Pro at a special price. If you need more information please contact your ADInstruments Representative.
For more information download the Software Booklet (5.83 MB) or contact your nearest ADInstruments Representative.
Sample Applications:
Dose Response Module applications involves studies with response to stimulation by chemical, electrical or physical agonists.
Sample applications include:
- Muscle Contraction of isolated tissues such as smooth, skeletal and cardiac muscles
- Enzyme Activity
- Hormone Secretion
- Heart Rate
- Blood Pressure
- Membrane Potential in response to stimulation by chemical, electrical or physical agonists
Features & Benefits:
- Complete data acquisition and analysis systems for in vivo and in vitro dose response applications.
- Real time and offline analysis.
- Automatic and manual display of single or multiple dose response curve calculation modes.
- Calculates EC50 and Hill Slopes.
- Extensive set of response calculation methods, based on LabChart selections:
- Average
- Maximum
- Maximum-Minimum (Response Height)
- Integral (Area)
- Minimum
- Optional baselines, flat and sloping.
- Simple, yet flexible, workflow:
- Enter a dose or list of doses.
- Mark dose point(s) on the data trace.
- Auto-analyze data or calculate responses from manual selections.
- Linked displays of Table View, Analysis View and Chart View.
- Table View provides centralized setup, display and data management functionality.
- Analysis View allows inspection and manual adjustment of calculation region and optional baseline for each response.
- Result View displays parameters of fitted sigmoid curves and provides for simultaneous display of multiple curves with optionally fixed top, bottom and hill-slopes.
- Data can be exported in XML and tab-delimited text format for use in other applications.
Screenshots & Videos:
Dose Response Overview.
Dose Response Chart View: Recording of a rat aortic blood pressure. The agonist injection points were marked during recording. Data were filtered to remove the individual beats to show only the average pressure per beat.
Dose Response Results View: The response points for the three channels and the fitted dose response curves are displayed. Fitting parameters for a selected curve are shown in the right and includes calculated parameters such as EC50 and Hill slopes with their respective standard errors.
Dose Response Analysis View: Shows data used to create a response selected in the Dose Response Table View. The markers for the response calculation region can be adjusted manually. The baseline can be dragged vertically, and the slope can be adjusted by dragging the handles on the left and right. Results are recalculated automatically when adjustments are made.
Dose Response Table View: Provides centralized setup, display and data management functionality. The value of each response in the Table View is linked with the corresponding display in the Dose Response Analysis View and Chart View. The results are automatically updated when different analysis selections are made.
Dose Response Settings and Detections: The Dose Response Settings dialog, users can choose to calculate average, maximum, minimum, amplitude or integral from each response. In the Auto-Analyze Selection dialog, users can set and start automatic analysis of marked Dose Response comments in LabChart data selection. The Convert Comments dialog identifies comments corresponding to changes in doses and converts these to “Dose” comments used by the module for analysis.
Dose Response Getting Started Tutorial: In-build tutorial software guides users through Dose Response Module settings of either online or offline data analyzing.
