The MLS390 Dose Response Module for Chart for Windows allows for the calculation of dose response type data from Chart recordings. The analysis can be done automatically or manually, offline or online. Chart data recorded prior to the use of the Module can be readily converted for use by Dose Response. The results of the analysis can be exported for use by other applications.
The Dose Response Module should be used with the latest version of Chart.
Example Applications
- muscle contraction
- enzyme activity
- hormone secretion
- heart rate
- blood pressure
- membrane potential
in response to stimulation by chemical, electrical or physical agonists.
 A Dose Response experiment and the results of the analysis.
Three simultaneous recordings of rat aortic blood pressure. The agonist injection points were marked during recording of the data, which were digitally filtered to remove the individual beats and show only
the average pressure per beat.  The response points for the three channels and the fitted response curves are displayed in the Dose Response Results View. Fitting parameters for a selected curve are shown in the list on the right. Features and Benefits:
- Offline and online analysis.
- Automatic and manual dose response calculations.
- Extensive set of response calculation methods, based on Chart selections:
- Optional baselines, flat and sloping.
- Simple, yet flexible, workflow (online or offline):
- Enter a dose or list of doses.
- Mark dose point(s) on the data trace.
- Auto-analyze data or calculate responses from manual selections.
- Linked displays in the Table View, Analysis View and Chart View.
- Table View provides centralized setup, display and data management functionality.
- Analysis View allows inspection and manual adjustment of calculation region and optional baseline for each response.
- Result View displays parameters of fitted sigmoid curves and provides for simultaneous display of multiple curves with optionally fixed top, bottom and hill-slopes.
- Data can be exported in XML and tab-delimited text format.
 The Analysis View with results from the analysis of the data shown above.
The Analysis View shows the data used to create the response selected in the Table View. The markers for the response calculation region can be adjusted manually. The baseline can be dragged vertically, and the slope can be adjusted by dragging the handles on the left and right. Results are recalculated automatically.  The Table View with results from the analysis of the data shown above.
Available as Part of Chart Pro
The Dose Response Module is also available as part of Chart Pro. Visit the Chart Pro information page prior to making a purchasing decision.
Existing Chart users and PowerLab system purchasers can upgrade to Chart Pro at a special price. If you need more information please contact your ADInstruments
Representative.
Brochure Download
For more information download the Dose Response Module brochure (860 KB) or contact your nearest ADInstruments
Representative.
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