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The MLS360 ECG Analysis Module for Windows automatically detects and reports PQRST onset, amplitude and intervals, either online or offline.
The ECG Analysis Module should be used with the latest version of Chart. Click here for the latest Chart Update for Windows.
 Chart recording of an ECG signal with a selection of ECG Analysis Module windows including ECG Averaging, ECG Table, ECG Waterfall Plot and ECG QT versus Time Plot. The raw data is unaltered by any calculations to ensure that the ECG can be reanalyzed. Default detection and analysis parameters are included for human, pig, dog, rabbit, guinea pig, rat and mice ECG. Detection settings can be customized at any time for optimization or for use with other animals.
The ECG Analysis Module should be used with the latest version of Chart for Windows.
ECG Settings
 ECG Settings Dialog.The ECG Settings dialog allows the user to select settings for a particular animal, as well as customizing the settings for optimal identification of the waveforms in the recorded ECG. The user also has the option to average a specified number of beats, or all the beats across a specified time period or in a block.
ECG Beat Classifier
 ECG Beat Classifier View.The ECG Beat Classifier enables the selection and removal of unsatisfactory beats or groups of beats. The left pane allows identification of beats with excessive ‘noise’ such as muscle activity. The pane on the right identifies beats with different RR intervals or altered QRS complexes. This pane enables ectopic beats and other cardiac arrhythmias to be easily identified. By positioning the movable red box limit lines over the desired group or groups and identified beats, the user selects the beats to be included for analysis. With the click of the ‘Accept All’ button the user is able to include all the beats in the left and right pane for analysis.
Beat Markers
 Recording of a Mouse ECG with markers identifying detected ECG beats.Once the appropriate setting has been chosen, the ECG Analysis Module automatically detects the ECG beats according to the ECG Settings.
Beat marker colors correspond to the signal’s “form” and “noise” factor selections in the ECG Beat Classifier View. The first beat marker is always displayed in gray. Beat markers included in analysis are green. Red marker color indicates exclusion from analysis based on signal noise. Blue color indicates exclusion due to form factor, and pink signifies exclusion due to noise as well as form.
ECG Averaging View
 ECG Averaging View. The ECG Analysis Module averages any chosen ECG beats within an ECG recording. The number of ECG beats averaged and analyzed together is dependent on the user’s selection in the ECG Settings dialog.
Apart from reducing the effects of noise and movement artifacts, averaging is useful when comparing effects on the ECG before and after experimental intervention. In the Averaging View, each average can be viewed individually and all PQRST markers can be adjusted manually if required. A red marker indicates that it was edited manually. The user also has the option of clearing manual edits by pressing the ‘Clear Edits’ button.
ECG Table View
The ECG Table View logs and displays selected ECG parameters. Available parameters are chosen in the ECG Table View dialog.
 ECG Table View Options Dialog.Values for each ECG average are automatically logged to the ECG Table View and can be added to the Data Pad (Chart’s internal spreadsheet) or the parameters can also be exported to graphing or statistical programs for further analysis. Real-time exporting to Excel can be performed through OLE linking.
 ECG Table View.The ECG Table View displays one row for each averaged beat. Any manual edits to markers in the Averaging View are displayed in red for the corresponding row in the ECG Table View. Rows are linked to the beats in the Averaging View so that highlighting a row will automatically show the corresponding averaged group, as well as these beats located within the Chart data file.
ECG Channel Calculations
 ECG Channel Calculation Dialog.Each of the parameters calculated by the ECG Analysis module can be displayed in a separate Chart Channel. ECG Channel calculations display the parameters of the averaged beats as they appear in the ECG Table View. This is particularly useful for online calculations.
ECG Plots
 QT interval versus Time for a Mouse ECG.Plots of QT Interval versus Time, QT Interval versus RR Interval and RR Interval versus Time can be automatically generated. These tools are ideal for illustrating effects of drugs on the interval times of an ECG waveform, in real time.
Waterfall plots can also be easily created using the ECG Analysis Module. Waterfall plots provide a three dimensional representation of an ECG. The generated plot is easily enlarged, reduced and rotated to provide the preferred viewing perspective.
 Waterfall Plots of Mouse (top) and Rabbit (bottom) ECG. Note the prolongated QT interval in the Rabbit ECG plot.Additional Information
Registered Chart v5 users can download an evaluation version of the ECG Analysis Module. The module is also available as part of Chart Pro. Visit the Chart Pro information page prior to making a purchasing decision. Existing Chart users and PowerLab system purchasers can upgrade to Chart Pro at a special price. If you need more information please contact your ADInstruments representative.
For more information download the ECG Analysis Module Brochure (345 KB) or contact your nearest ADInstruments Representative.
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