Telemetry
Overview:
Traditional tethered systems limit the recording environment when monitoring physiological signals such as ECG, EMG, EEG, EOG and nerve activity in conscious animals. Telemetry is a wireless technology that allows recording and transfer of information of interest from a remote system, and therefore expands the range of monitoring capabilities. The word is derived from Greek, which “tele” means remote, and “metron” means measure.
Method:
ADInstruments offer a range Telemetry Research systems for measuring biopotentials such as ECG and sympathetic nerve activity in small and large animals. These systems incorporate the following components:
- Transmitter – (fully implantable) detects, amplifies and transmits (transmission range up to 5 m depending on laboratory conditions) data to the remote receiver.
- Receiver - receives digital data from the transmitter and reconstructs an analog output which is compatible with PowerLab data acquisition systems.
- Wireless Power Charger – recharges the transmitter without wires while the transmitter is still within the animal using inductive power transfer (IPT)
- Data Acquisition Hardware and Software - Powerlab with LabChart software provides fast and easy monitoring, recording and analysis.
The features and benefits of these systems include:
- High sampling rates for accurate signal recording
- Transmitters with a controlled power-down function to extend the life of the battery
- Transmitter batteries which are recharged wirelessly
- 12 independent transmission frequencies: Eliminates the need for special housing or animal isolation (ie. animals with different transmitters can be housed in the same cage)
- Digital transmission up to 5 meters
Scheduling
These systems include the ML319 TR Scheduler Pod and LabChart Scheduler Extension, allowing the user to program recording periods. The scheduler allows the user to:
- automate data collection from up to 12 wireless transmitters with a single receiver
- allows data recording durations of seconds, minutes or hours of data for periods over days to weeks
- extend the life of the transmitter battery by powering-down the transmitter when not recording data
Software:
LabChart
LabChart software (for Windows and Macintosh) combines the familiar simplicity of a traditional strip chart recorder with the powerful analysis features of a digital acquisition system. LabChart software and a PowerLab data acquisition unit provide data integrity, easy selection of hardware settings, powerful online and offline analysis, procedure automation, seamless extraction of experimental data and flexible display options. Acquisition and analysis capabilities can be further increased with LabChart Extensions and LabChart Modules. LabChart Modules are available as part of LabChart Pro and LabChart Extensions are free for download from the website for existing LabChart users.
LabChart users can calculate and display online or offline heart rate using features such as Cyclic Measurements (Cycle variables, Mac) in LabChart. The mean and standard deviation of the heart rate can also be calculated (over any time interval) using the Data Pad feature in LabChart.
SNA Analysis
The Shift Extension (Mac) in LabChart allows the sympathetic nerve recording to be shifted back in time so that the peak of each sympathetic burst is aligned to the R-wave of the ECG. Amplitude, area, slope, duration and other features of the RMS-processed/integrated nerve signal can be readily measured using the Peak Parameters extension (Win or Mac) and added to the Data Pad for export to statistics programs.
ECG Analysis Module (Windows)
The MLS360/7 ECG Analysis Module provides a comprehensive set of tools that automatically detects and reports values of ECG recordings. The software can be used with ECG recordings taken from humans and many species of animals from pigs through to mice.
It provides
Heart Rate Variability (HRV) Module (Windows or Macintosh)
The MLS310 HRV Module provides a comprehensive set of tools for the analysis and display of variation in the interval between heartbeats in human and animal electrocardiogram recordings.
The HRV Module:
- Detects and analyzes R waves & RR interval variation in ECG real-time or offline recordings
- Includes or excludes ectopic beats from analysis
- Adds R waves or remove short artifacts from analysis
- Provides data export options
- Provides automated HRV Analysis Windows
GLP and 21 CFR Part 11
For those researchers working within a laboratory requiring GLP and 21 CFR Part 11 compliance the GLP Client and GLP Server are available for use with LabChart (Windows only) and PowerLab data acquisition systems. For more information, visit the Good Laboratory Practice application page or contact your nearest ADInstruments representative.
Hardware:
Data Recording and Analysis
PowerLab data acquisition systems and LabChart/Scope software are ideal for biopotential recordings due to their ability to record at high sampling rates. They include:
- ML866 PowerLab 4/30 – 4 channels
- ML870 PowerLab 8/30 – 8 channels
- ML880 PowerLab 16/30 – 16 channels
Telemetry Pressure Foundation Systems
The ML880B108 Telemetry Blood Pressure Foundation System (Millar) can be used to record and analyze intravascular or intralumen pressure as well as body temperature, from conscious small animals (>200 g), wirelessly from individual compatible telemetry transmitters. However, transmitters are NOT included in this system and must be selected (number, type and size) and purchased separately.
Recommended transmitters are:
- MLE1024 TR/Millar Pressure Transmitter (Small Animal, TRM53P) with the MLE1005CPS Wireless Continuous Power Supplier (Small Animal, Millar, TR803)
The ML880B104 Telemetry Blood Pressure Foundation System can be used to record and analyze intravascular or intralumen pressure as well as body temperature, from conscious animals, wirelessly from individual compatible telemetry transmitters. However, transmitters are NOT included in this system and must be selected (number, type and size) and purchased separately
Recommended transmitters are:
- MLE1015 Telemetry Pressure Transmitter (TR73P for all animals »1.5 kg) with the MLE1007WPC Wireless Power Charger (Large Animal, TR871)
Both systems include the ML319 TR Scheduler Pod and LabChart Scheduler Extension, allowing the user to schedule recording periods and record data sequentially from individual transmitters. Continuous 24 hour simultaneous charging/recording is also supported for small animal transmitters with appropriate wireless continuous power suppliers and subsidiary receivers
Telemetry Biopotential Foundation System
The ML880B103 Telemetry Biopotential Foundation System is designed to record and analyze one biopotential signal such as ECG EMG, EOG or EEG, as well as body temperature, from conscious animals, wirelessly from individual compatible telemetry transmitters.
Recommended transmitters are:
- MLE1010 Telemetry Biopotential Transmitter (TR40B for small animals »200 g) with the MLE1006CPS Wireless Continuous Power Supplier (Small Animal, TR802)
- MLE1011 Telemetry Biopotential Transmitter (TR70B for large animals »1.5 kg) with the MLE1007WPC Wireless Power Charger (Large Animal, TR871)
The system includes the ML319 TR Scheduler Pod and LabChart Scheduler Extension, allowing the user to schedule recording periods and record data sequentially from individual transmitters. Continuous 24 hour simultaneous charging/recording is also supported for small animal transmitters with appropriate wireless continuous power suppliers and subsidiary receivers.
Telemetry Pressure and Biopotential Foundation System
The ML880B105 Telemetry Pressure and Biopotential Foundation System is designed to record and analyze intravascular or intralumen pressure and one biopotential signal such as ECG, EMG, EOG or EEG, as well as body temperature, wirelessly from individual compatible telemetry transmitters. However, transmitters are NOT included in this system and must be selected (number, type and size) and purchased separately.
Recommended transmitters are:
- MLE1016 Telemetry Pressure and Biopotential Transmitter (TR43PB for small animals » 200 g) with the MLE1006CPS Wireless Continuous Power Supplier (Small Animal, TR802)
- MLE1017 Telemetry Pressure and Biopotential Transmitter (TR73PB for all animals » 1.5 kg) with the MLE1007WPC Wireless Power Charger (Large Animal, TR871)
The system includes the ML319 TR Scheduler Pod and LabChart Scheduler Extension, allowing the user to schedule recording periods and record data sequentially from individual transmitters. Continuous 24 hour simultaneous charging/recording is also supported for small animal transmitters with appropriate wireless continuous power suppliers and subsidiary receivers.
Telemetry Dual Biopotential Foundation System
The ML880B106 Telemetry Dual Biopotential Foundation System is designed to record and analyze two biopotential signals such as ECG, EMG, EOG or EEG, as well as body temperature, wirelessly from individual compatible telemetry transmitters. However, transmitters are NOT included in this system and must be selected (number, type and size) and purchased separately.
Recommended transmitters are:
- MLE1012 Telemetry Dual Biopotential Transmitter (TR40BB for small animals »200 g) with the MLE1006CPS Wireless Continuous Power Supplier (Small Animal, TR802)
- MLE1013 Telemetry Dual Biopotential Transmitter (TR70BB for all animals » 1.5 kg) with the MLE1007WPC Wireless Power Charger (Large Animal, TR871)
The system includes the ML319 TR Scheduler Pod and LabChart Scheduler Extension, allowing the user to schedule recording periods and record data sequentially from individual transmitters. Continuous 24 hour simultaneous charging/recording is also supported for small animal transmitters with appropriate wireless continuous power suppliers and subsidiary receivers.
Telemetry SNA and Pressure Foundation System
The ML880B107 Telemetry SNA and Pressure Foundation System can be used to record and analyze Sympathetic Nerve Activity (SNA) in addition to intravascular or intralumen pressure in small and large animals, as well as body temperature, wirelessly from individual compatible telemetry transmitters. However, transmitters are NOT included in this system and must be selected (number, type and size) and purchased separately.
Recommended transmitters:
- MLE1022 Telemetry SNA and Pressure Transmitter (TR46SP for small animals »200 g) with the MLE1006CPS Wireless Continuous Power Supplier (Small Animal, TR802)
- MLE1023 Telemetry SNA and Pressure Transmitter (TR76SP for all animals »1.5 kg) with the MLE1007WPC Wireless Power Charger (Large Animal, TR871)
The system includes the ML319 TR Scheduler Pod and LabChart Scheduler Extension, allowing the user to schedule recording periods and record data sequentially from individual transmitters. Continuous 24 hour simultaneous charging/recording is also supported for small animal transmitters with appropriate wireless continuous power suppliers and subsidiary receivers.
Accessories
The MLE1150 Telemetry Antenna Extension (TRAntX) for Telemetry Receivers consists of a four meter extension cable between receiver and antenna. The antenna extension enables the antenna to be placed closer to the animal in large animal cages, in situations where the receiver cannot be placed near cage
The MLE1140 Blood Pressure Starter Pack with instruments (TRStartBP) includes surgical instruments and components required to implant arterial transmitters in rats
The MLE1142 SNA Consumable Pack includes consumable items required to implant SNA transmitters in rats (excludes surgical instruments)
The MLE1145 TR/Millar BP Consumable Pack (TRsbBP) includes includes a practice TRM53P transmitter (x1) and consumable items required to implant TR/Millar pressure transmitters in rats (excludes surgical instruments)
The SP0128 Silicone Elastomer for securing the SNA Telemetry probes to the nerve is a two-part silicone elastomer. It includes two 5 mL syringes and mixing tips.
ADInstruments also provides a limited range of analog adapters for with DSI telemetry transmitters (measuring ECG temperature and blood pressure). Please contact your nearest ADInstruments representative for more information.
Simvastatin normalizes automonic neural control in experimental heart failure
R U Pliquett, K G Cornish, J D Peuler and I H Zucker, Circulation, 2493-2498, 2003
Aging and the exercise pressor reflex in humans
T A Markel, J C Daley III, C S Hogeman, M D Herr, M H Khan, K S Gray, A R Kunselman and L I Sinoway, Circulation, 675-678, 2003
The material on this page is provided in good faith and believed accurate at the time of writing. No responsibility will be taken, or liability accepted, for damages arising from the use of information herein. Readers are urged to check with respective manufacturers the accuracy of all product related information.
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