Here at ADInstruments, we're lucky to be a part of a large and thriving research community. Join us in celebrating some of the incredible work that has been published by that community in September 2024.
Protein Kinase N Promotes Cardiac Fibrosis in Heart Failure by Fibroblast-to-myofibroblast Conversion.
Published in Nature Communications
Yoshida et al., investigate the role of protein kinase N (PKN) in the development of cardiac fibrosis, a key factor in heart failure progression. Their research reveals that PKN1 and PKN2 are expressed in cardiac fibroblasts, where they mediate the conversion of fibroblasts to myofibroblasts through the phosphorylation of p38 MAPK. This process leads to excessive extracellular matrix deposition, contributing to fibrosis and cardiac
The structure of Protein Kinase N1
dysfunction. The study further demonstrates that inhibiting PKN in mouse models reduces fibrosis and preserves cardiac function, positioning PKN as a potential therapeutic target for treating heart failure.
Read more: https://doi.org/10.1038/s41467-024-52068-0
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Impact of Right Ventricular Pressure Overload on Myocardial Stiffness Assessed by Natural Wave Imaging.
Published in JACC. Cardiovascular Imaging
Example ECG data in LabChart
In this article, Venet et al. explore the use of ultrafast ultrasound imaging to measure myocardial stiffness in the right ventricle under pressure overload conditions. The study utilized rodent models and human subjects, comparing those with right ventricle pressure overload to healthy controls. It found that natural wave velocity, which indicates myocardial stiffness, was significantly higher in pressure overload conditions. The results suggest that natural wave velocity can be used as a noninvasive indicator of both systolic and diastolic stiffness, offering insights into cardiac function and the progression of right ventricle failure.
Read more: https://doi.org/10.1016/j.jcmg.2024.06.020
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Modified C-type Natriuretic Peptide Normalizes Tumor Vasculature, Reinvigorates Antitumor Immunity, and Improves Solid Tumor Therapies.
Published in Science Translational Medicine
Lu et al., explore the potential of a modified C-type natriuretic peptide (dCNP) as a novel approach to treat solid tumors. It highlights how dCNP normalizes tumor blood vessels, reduces hypoxia, and alleviates immunosuppressive conditions within the tumor microenvironment. The study demonstrates that dCNP not only decelerates tumor growth and metastasis in preclinical models but also enhances the effectiveness of
The chaotic vasculature typical to tumors
chemo-, radio-, and immunotherapies, positioning it as a promising therapeutic option for improving solid tumor treatments.
Read more: https://doi.org/10.1126/scitranslmed.adn0904
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Protein Kinase C Epsilon Contributes to Chronic Mechanoreflex Sensitization in Rats With Heart Failure.
Published in The Journal of Physiology
The structure of Protein Kinase C epsilon (PKCε)
Butenas et al., investigate the role of protein kinase C epsilon (PKCε) and inositol 1,4,5-trisphosphate (IP3) receptors in chronic mechanoreflex sensitization in rats with heart failure with reduced ejection fraction (HF-rEF). The study found that while IP3 receptor inhibition had no effect, blocking PKCε reduced the exaggerated sympathetic responses during muscle stretch in HF-rEF
rats, highlighting PKCε's crucial role in the exaggerated reflex. These findings are significant in understanding the heightened cardiovascular risks during exercise in heart failure patients.
Read more: https://doi.org/10.1113/jp287020
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Role of the Peripheral Chemoreceptors in Cardiovascular and Metabolic Control in Type 2 Diabetes.
Published in The Journal of Physiology
In this article, Limberg et al. examine how peripheral chemoreceptors contribute to cardiovascular and metabolic dysfunction in adults with Type 2 diabetes. The study finds that individuals with Type 2 diabetes exhibit exaggerated peripheral chemoreflex sensitivity to hypoxia, which is associated with poor glycaemic control (higher levels of glycated hemoglobin). Despite this elevated chemosensitivity, acute inhibition of peripheral chemoreceptors using hyperoxia did not improve cardiovascular or glucose tolerance in these individuals, suggesting that targeting peripheral chemoreceptor
A Human NIBP monitor being fitted to a participant
activity may not be an effective therapy for immediate restoration of cardiometabolic function in Type 2 diabetes.
Read more: https://doi.org/10.1113/jp286975
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