Animal welfare, scientific, and financial benefits can be realized in research applications through the in vivo collection of Continuous Glucose Telemetry data.
The benefits of continuous glucose telemetry achieved by providing glucose, temperature, and activity measurements each second for a period of 4-8 weeks, while only requiring three or less blood samples per week.
1 - Improved Animal Welfare
Continuous Glucose Telemetry allows you to refine1 animal welfare by reducing exposure to stress and pain through:
- Fewer blood draws
- Reduced handling
- Fewer animals required
- Minimized human presence
Animal reduction1 often occurs as a result of either or both:
- Higher quality data and advanced study options providing the same statistical power with lower sample sizes
- Reduced blood sampling allowing increased frequency of assays and more efficient use of animals
2 - Higher Quality Data
“It is generally acknowledged that the quality of physiological measurements collected from conscious unstressed animals is superior, since they are collected under conditions that best represent the normal state of the animal, are least influenced by chemical, stress, and psychological factors and (where appropriate) are most predictive of the results that would be achieved in human beings.” 2
The fact that this higher quality data is collected continuously further enhances the quality of the data due to the volume of measurements and ability to minimize effects of noise.
3 - Advanced Study Options
Stress-free, continuous glucose data enables you to perform studies and quantify data in ways not possible or feasible with intermittent sampling.
- Use animals sequentially as their own control
- Detect subtle changes that would otherwise be missed
- Opportunity for quantification of new and improved biomarkers such as glucose homeostasis, glycemic variability, rate of change to a stimulus, time to an event, time within a range, and more.
4 - Cost Savings
The combination of reduced handling, fewer blood draws, and smaller sample sizes leads to significant savings in labor, consumables, assays, husbandry, test compound, and more. The reduction in labor allows for the application of labor elsewhere helping you to get more done with the same resources.
NO MORE DATA GAPS
Detect second-to-second changes in blood glucose to capture a complete glucose profile that ensures you don’t miss significant events. Using LabChart, combined with the HD-XG glucose implants for your glucose research allows for more sophisticated experiment design, observation of disease development over long periods (28 days or more), with significantly less stress to animals and lower researcher workloads. Selecting the HD-XG glucose implants to use with our Biopotential and Glucose Telemetry Foundation System gives you the perfect all-in-one solution for your glucose research.
Ideal for research in the fields of Diabetes & Obesity, Endocrinology & Metabolism, and Sports & Exercise.
Contact us to discuss your specific research application and the significant benefits this system can have for your glucose research and workflow.
1The 3Rs. http://nc3rs.org.uk/the-3rs. Accessed 13 April 2018.
2 Kramer K, Kinter LB. Evaluation and applications of radiotelemetry in small laboratory animals. Physiological Genomics 2003;13(3):197–205. doi:10.1152/physiolgenomics.00164.2002