Optogenetic Stimulation for Parkinson’s Research: Recovering Movement in an Animal Model

Introduction


Optogenetic Stimulation for Parkinson's Webinar

The American Physiological Society (APS), ADInstruments, and InsideScientific are pleased to present this upcoming webinar with Louise Parr-Brownlie, PhD and Conor Underwood, PhD on Optogenetic Stimulation for Parkinson's Research.

This webinar with provide a review of implantable optogenetics to replace deep brain stimulation, a surgical procedure overview, and a discussion about the impact of acute optogenetic stimulation for the treatment of Parkinson's disease in a rat model.

Electrical deep brain stimulation is an effective treatment for people living with Parkinson’s disease. However, some patients experience stimulation-induced side effects, such as cognitive decline and worsening of gait. Non-selective electrical stimulation of neurons and anatomical pathways underlies some of these side effects.

Louise and Conor hypothesized that optogenetic stimulation might be a highly-selective alternative to deep brain stimulation, which might avoid some of the harmful side-effects of electrical stimulation. They have found that acute optogenetic stimulation of the motor thalamus can recover movements in a rat model of Parkinson’s disease. As a critical step to translating optogenetic stimulation to humans, their study optimized the design of an implantable device to deliver chronic (2 months) motor thalamus stimulation in Parkinsonian rats to ultimately improve movements, including activities of daily living. Surgical implantation of these devices is technically demanding, and the limited fiber flexibility makes this more challenging. In this webinar, Louise and Conor will outline the surgical procedure, post-operative management requirements, and will discuss this study and the future directions for their work.


DATE: Tuesday April 26, 2022

START TIME: 1:00pm PT | 4:00pm ET | 6:00am AET

DURATION: 60 Minutes

Reserve Your Spot!


Topics Include:

  • Understanding how a chronically implanted optogenetic stimulation device functions and how it was developed
  • Reviewing the surgical procedure to chronically implant the Kaha Sciences Optogenetics Biopotential Telemeter from ADInstruments
  • Discussing the tips and tricks for post-operative care and management for this procedure

Presenters: 
 

Louise Parr-Brownlie | Assistant Professor, University of Otago

Louise Parr-Brownlie, PhD
Associate Professor, Anatomy, University of Otago

Louise Parr-Brownlie completed her PhD in neurophysiology then held research positions at the NIH. Louise has characterized changes in neuronal activity in motor pathways in models of Parkinson’s disease, examined if motor thalamus stimulation can recover movements, and worked with bioengineers to develop implantable light stimulation devices.
 

Conor Underwood | Post-Doctoral Fellow, University of Otago

Conor Underwood, PhD
Post-Doctoral Fellow, Anatomy, University of Otago

Dr. Conor Underwood is a passionate early-career scientist with a keen interest in novel technologies for neuroscience research. His research aims to characterize and treat thalamocortical dysfunction in Parkinson's disease (post-doc) and hypothalamic dysfunction in kidney disease (PhD).
 


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Schedule

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