Dual Epithelial Voltage Clamp System

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Product code: PL3508B78-V

The Dual Epithelial Voltage Clamp System is designed to study of epithelial transport and the electrical properties of tissues with a compatible Ussing Chamber.

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Overview

The Dual Epithelial Voltage Clamp System is designed to be used with a corresponding Ussing Chamber for studies of epithelial transport and the electrical properties of epithelial samples (tissue or cell layer). It allows up to two simultaneous signal measurements that can include transepithelial voltage, short circuit current and membrane resistance. This system can be used with various Ussing Chamber designs, including the Self-Contained Ussing Chamber and NaviCyte Vertical Ussing Chamber series.

Each System includes:

PowerLab 8/35 and LabChart Pro software
19 Inch Rack Adapter
Dual Channel Epithelial Voltage Clamp (50 V)

Self-Contained Ussing Chamber Options (purchased separately):

NaviCyte Vertical Ussing Chamber System Options (purchased separately):

Features

Differential voltage recordings are made with very high common mode rejection (CMR) providing accurate measurements free from the effects of common mode potential changes of a noisy environment.
Membrane Resistance Measurement Circuit using a low frequency 2 Hz bipolar signal to avoid polarization of the membrane (ideal for monolayers).
Three Clamp Speeds selection provide optimum recording conditions for a variety of applications, such as Fast mode (as fast as 10 µsec) for preparations with low access resistance (small tissues or monolayers) and Medium or Slow modes for stable, oscillation free clamping in larger tissues.
Operating modes include voltage clamp, current clamp, voltmeter, and resistance.
Independent Voltage and Current Commands.
Internal DC Command (Hold) control for both Voltage clamp and Current clamp modes.
The clamp can be operated by an external programmer, lab timer or computer - logic control of clamp mode and clamp command levels is possible as well as simultaneous mixing of external linear commands.
Watertight Headstage with Model Membrane

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Details and Tech Specs

Technical

Ordering Information

When ordering please specify the following: Mains Power (V) = 115 for 110-115 V or 220 for 220-240 V.

Specifications

Headstage

Input Impedance: 1 x 10¹⁰ Ω shunted by 6 pF
Input Voltage: ±1.5 V maximum
Common Mode Voltage: ±13 V maximum
Common Mode Rejection: 100 dB at 60 Hz
Leakage Current: 20 pA maximum
Offset Voltage Range: ±120 mV

Voltage Clamp Ranges

Int. Clamp Potentiometer: ±100 mV with 10-turn control
Ext. Command: ±1 V
Ext. Command Factor: 1 mV/10 mV applied

Current Clamp Ranges

Clamp Potentiometer: ±1 mA
External Command: ±10 mA
Command Factor: 1 µA/10 mV applied
Speed: 10 µs measured with model membrane

Resistance

Fluid Resistance: 0-100 Ω standard
Compensation Range: 0-1 kΩ optional
Membrane Resistance Measurement: made with 2 Hz bipolar constant current square wave
Ranges: 0-2 kΩ, injected current = 10 nA; 0-200 kΩ, injected current = 1 nA
Membrane Resistance: 0-2 kΩ, 1mV/Ω
Output: 0-200 kΩ, 10mV/Ω
Panel Meter: 3-1/2 digit LCD; Voltage Range: 200 mV max; Current Range: 2000 µA max

Outputs