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Thank you for your interest in Patch Clamp Amplifiers. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.

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Patch Clamp Amplifiers

PC-501A/9-V, PC-501A/8-V, PC-501A/10-V

Configurations


Patch Clamp Amplifier with 1 GΩ Headstage

PC-501A/9-V

9 V Patch Clamp Amplifier with 1 GΩ Headstage suitable for whole cell studies with currents to ±10 nA.


Patch Clamp Amplifier with 10 GΩ Headstage

PC-501A/10-V

10 V Patch Clamp Amplifier with 10 GΩ Headstage suitable for recording single channel currents up to ±1 nA.


Patch Clamp Amplifier with 100 MΩ Headstage

PC-501A/8-V

8 V Patch Clamp Amplifier with 100 MΩ Headstage suitable for whole cell studies with currents to ±100 nA.


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Patch Clamp Amplifiers

PRICE ON REQUEST

Suitable for measuring currents in single channel measurements or whole cell studies, and is available with several choices of headstages.

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Overview

These workhorse patch clamp amplifiers by Warner Instruments are ideal equally for research and teaching applications. They are used with various headstages, suitable Q Series Electrode Holders and glass microelectrodes (purchased separately) to measure corresponding currents in single channel measurements or whole cell studies. Measured signals can then be recorded and analysed with a PowerLab and LabChart data acquisition system. 

The amplifiers feature:

  • independent V-hold and I-hold circuitry
  • three current clamp response speeds that increase stability of large membrane clamps
  • internally generated test signals
  • filters and compensation options

A headstage must be selected and included when purchasing a patch clamp amplifier. Additional headstages may be ordered separately. A patch clamp amplifier and corresponding headstage are also included when purchasing Patch Clamp Recording Systems

Accessories:

Configurations


Patch Clamp Amplifier with 1 GΩ Headstage

PC-501A/9-V

9 V Patch Clamp Amplifier with 1 GΩ Headstage suitable for whole cell studies with currents to ±10 nA.

Patch Clamp Amplifier with 10 GΩ Headstage

PC-501A/10-V

10 V Patch Clamp Amplifier with 10 GΩ Headstage suitable for recording single channel currents up to ±1 nA.

Patch Clamp Amplifier with 100 MΩ Headstage

PC-501A/8-V

8 V Patch Clamp Amplifier with 100 MΩ Headstage suitable for whole cell studies with currents to ±100 nA.

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Patch Clamp Amplifier with 1 GΩ Headstage

Patch Clamp Amplifier with 1 GΩ Headstage

PC-501A/9-V

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Patch Clamp Amplifier with 10 GΩ Headstage

Patch Clamp Amplifier with 10 GΩ Headstage

PC-501A/10-V

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checkmark Item successfully added to your quote request.
Patch Clamp Amplifier with 100 MΩ Headstage

Patch Clamp Amplifier with 100 MΩ Headstage

PC-501A/8-V

Features

  • Independent V-hold and I-hold circuitry
  • Three current clamp response speeds increase stability of large membrane clamps 
  • 4-pole low-pass Bessel filter 
  • Internally generated test signals 
  • Variable duration zap circuit

Support

Support Articles

Our Support Articles contain answers to common questions, how-tos, solutions, and documentation.

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Details and Tech Specs

Product Codes


PC-501A/9-V
Patch Clamp Amplifier with 1 GΩ Headstage
PC-501A/10-V
Patch Clamp Amplifier with 10 GΩ Headstage
PC-501A/8-V
Patch Clamp Amplifier with 100 MΩ Headstage

Technical

Ordering Information: 
When ordering a Patch Clamp Amplifier please specify the following: Mains Power (V) = 115 for 110-115 V or 220 for 220-240 V.

Simple modifications to the Patch Clamp Amplifiers can also make them suitable for voltammetric measurements. They include increasing the holding voltage potential to ±1 V and the external voltage signal level to ±2 V maximum. Internal switches can be installed to allow switching between normal (patch) and voltammetry operation.

Operating Modes:

V Clamp Mode: Input is clamped to a maximum of ±1 V. Commands are the sum of the holding voltage and any external input signals.
Zero Current Mode: Bridges the voltage and current clamp modes. All commands are inactive except the junction zero, which functions in this case as an offset control for the electrode and tip potentials associated with the pipette.
I Clamp Mode: In the current clamp mode, active commands are the current hold and any external command input signals, summed. Clamp stability is enhanced with the selection of three clamp speeds.

Compensation Controls:

Voltage Offsets (including junction potentials): Automatically compensated with the auto zero or manually with the junction zero.
Capacity Compensation: Paired controls; fast (0-5 µs), medium (0-2 ms) and slow (0-20 ms) compensate the current transient caused by a step command signal. Each pair has a separate control for amplitude and time constant.
Series Resistance: Signal errors contributed by the electrode (access) resistance in whole cell recording are subtracted from the output with the series R comp control. The compensated resistance (0-100 MΩ) is read from a ten turn dial.
Leak Subtract: Used to compensate leakage current due to the voltage drop across the seal (shunt) resistance.

Outputs/Signal Conditioning:

The membrane current signal Im is bandwidth limited by a 4-pole Bessel filter with six frequency cut-offs and can be bypassed to obtain the full 10 kHz bandwidth. Gain is selected with a 7 position switch and scaled to the headstage resistor.

Additional outputs are Vm x 10 (membrane voltage at x10 gain) active in current clamp mode and Vc x 10, the sum of all commands at x10 gain. Rear panel outputs include; gain telegraph, a DC signal which communicates to a data acquisition system the Im output gain level and the headstage in use, and sync output, a signal to synchronize an oscilloscope or computer with one of the internal test signals.

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