How is a dilated cardiomyopathy characterized by left ventricle pressure volume loops?

Dilated Cardiomyopathy (or congestive cardiomyopathy) (DCM) is a condition resulting from an enlarged heart (LV dilation) and is caused by coronary artery disease or valve disease. DCM increases end-diastolic volume (EDV) and end-systolic volume (ESV). However, the weakening of the heart causes a decrease in end-systolic pressure (ESP). Thus, the slope of the end-systolic pressure volume relationship (ESPVR) decreases. The slope of the end-diastolic pressure volume relationship (EDPVR) decreases which signifies an increase in compliance (decrease in vascular stiffness). Stroke work and cardiac output are also depressed.


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