CaV2.3 channels in the mouse central medial thalamic nucleus are essential for thalamocortical oscillations and spike wave discharges
Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors
Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment
Abstract Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. So, we aimed to use iron chelato…
Differential encoding of mammalian proprioception by voltage-gated sodium channels
Animals requiring purposeful movement for survival are endowed with mechanoreceptors, called proprioceptors, that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of…
Methylcobalamin-containing nanofiber sheets have better neuroprotective effects than small intestinal submucosa sheets
Morphological and functional decline of the SNc in a model of progressive parkinsonism
Abstract The motor symptoms of Parkinson’s Disease are attributed to the degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). Previous work in the MCI-Park mouse model has suggested that the loss of somatodendritic dopamine…
Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition
Optogenetic quantification of cardiac excitability and electrical coupling in intact hearts to explain cardiac arrhythmia initiation
Increased cardiac excitability and reduced electrical coupling promote cardiac arrhythmia and can be quantified by input resistance ( R m ), pacing threshold ( I…