Pharmacology + Isolated Tissue and Organs Research

Modular designs with high-quality glassware to suit your experiments

In vitro pharmacological studies use tissue-organ bath and organ perfusion apparatuses to study and record pharmacological responses in a controlled environment, free from in vivo influences. Measured parameters can include isometric force, displacement, pressure and biopotentials. ADInstruments provides a wide range of high quality modular designs that include various tissue-organ bath chambers and tissue supports to suit almost any tissue size, type and orientation.

Isolated Organs

Advantages of Isolated Tissue-Organ Research

Isolation from in vivo Influences

Study the intrinsic physiological properties and responses of isolated tissue samples without any impacting factors from the body.

Comprehensive Environmental Control

Determine and maintain the environmental parameters, such as temperature, oxygenation, pH and nutrients, reducing variables from impacting your results.

Precise Stimuli Addition and/or Removal

Investigate tissue responses quickly by introducing any number of agonistic or antagonistic stimuli, such as drugs and electrical stimulation with precise control of their duration and amount.

Modular Designs Allow Easy Upgrades and Experimental Expansion

Easily scale up or down the complexity of the modular apparatus to match the needs of your experimental protocol.

Typical Studies

  • Pharmacology and toxicology
  • Cardiovascular
  • Myocardial tissue and blood vessels
  • Myology
  • Respiratory Tissue
  • Neurophysiology
  • Contractile studies of isolated tissues
  • Dose response studies
  • Isolated perfused organ studies
  • Ischemia-reperfusion studies
  • Medical device testing
  • Organ modeling and artificial organ studies

Radnoti Isolated Tissue-Organ Systems

High-quality Glassware That Remains Crystal Clear

High-quality Glassware That Remains Crystal Clear

Radnoti's high-quality borosilicate scientific glassware is chemically inert, corrosion and scratch resistant, remaining clear and transparent even after decades of constant use.

Myriad Customizations with Modular Designs

Myriad Customizations with Modular Designs

Select from preconfigured apparatus, modify existing designs, or tailor your own design from a vast range of compatible components. Easily upgrade or extend your design with additional components, or repurpose components for a new research direction. Radnoti’s modularity gives you the flexibility to design systems that work for you.

Temperature Management You Can Trust

Temperature Management You Can Trust

End-to-end water jacketing ensures that every component reaches and maintains the correct temperature. This closed system keeps your system warm without risking contamination from open water reservoirs, and minimizes the risk of temperature drops.

Easy To Clean, Easy To Maintain

Easy To Clean, Easy To Maintain

All Radnoti glassware is autoclavable. With a focus on modularity and customization, we've made it easy to set up, pack down, and clean up your isolated systems as quickly and painlessly as possible.

Glassware with Quick and Seamless Tubing Connections

Glassware with Quick and Seamless Tubing Connections

Radnoti's Quick Disconnect design allows you to easily attach or remove glassware components from tubing circuits for cleaning, replacement or redesign. Manufactured with high-quality luer port connections, Radnoti glassware provides seamless tubing connections and prevents fluid leakage.

Easy Integration with a Wide Range of Transducers and Instruments

Easy Integration with a Wide Range of Transducers and Instruments

Radnoti apparatuses are designed with multiple port options compatible with the wide range of transducers and sensors available from ADInstruments. Easily attach your selected sensor or transducer to record and analyse data with powerful ADInstruments PowerLab and LabChart software.

 

Real Results in Research

Dr Melanie White
University of Sydney

Best Practices when using the Langendorff

Dr Lei Fan

Dr Lei Fan
The Marquette University and Medical College of Wisconsin

Computational Modeling and the Working Heart

Dr André Leite Moreira

Dr André Leite Moreira
University of Porto

Exploring Working Heart Systems

Dr Tina Myhre Pedersen

Dr Tina Myhre Pedersen
University of Tromsø

Exploring Working Heart Systems

Citations

Radnoti Isolated Tissue-Organ systems have been tested and validated in studies ranging from basic physiology and cell functioning to drug and treatment development.

  • Metabolic reprogramming by immune-responsive gene 1 upregulation improves donor heart preservation and function. Lenglam Lei, Wei Huang, Pierre Emmanuel Noly, Suyash Naik, Miriyam Ghali, Liu Liu, Francis D Pagani, Ashraf Abou El Ela, Jordan S Pober, Bertram Pitt, Jeffrey L Platt, Marilia Cascalho, Zhong Wang, Y Eugene Chen, Richard M Mortensen, Paul C Tang Science Translational Medicine, 15(682), 2023 

    Age, Sex and Overall Health, Measured As Frailty, Modify Myofilament Proteins in Hearts From Naturally Aging Mice. Alice E. Kane, Elise S. Bisset, Kaitlyn M. Keller, Anjali Ghimire, W. Glen Pyle, Susan E. Howlett Scientific Reports, 10(1), 2020 

    Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice. Rachel A Collins, Rosa C Gualano, Graeme R Zosky, Constance L Atkins, Debra J Turner, Giuseppe N Colasurdo & Peter D Sly Respiratory Research, 6(1), 2005 

    Multiple Mass Isotopomer Tracing of Acetyl-CoA Metabolism in Langendorff-perfused Rat Hearts: Channeling of Acetyl-CoA from Pyruvate Dehydrogenase to Carnitine Acetyltransferase. Qingling Li, Shuang Deng, Rafael A. Ibarra, Vernon E. Anderson, Henri Brunengraber, and Guo-Fang Zhang Journal of Biological Chemistry, 290(13), 2015 

  • An Isolated Working Heart System for Large Animal Models. Matthew A. Schechter, Kevin W. Southerland, Bryan J. Feger, Dean Linder Jr., Ayyaz A. Ali, Linda Njoroge, Carmelo A. Milano, Dawn E. Bowles Journal of Visualized Experiments, 2014 

    Cardiac Toxicity of Azole Antifungals. John D. Cleary, Kayla R. Stover, Jerry Farley, William Daley, Patrick B. Kyle, Jon Hosler Pharmacology & Pharmacy, 04(03), 2013 

    A Model for Normothermic Preservation of the Rat Liver. H Tolboom, R Pouw, K Uygun, Y Tanimura, M-L Izamis, F Berthiaume, M L. Yarmush Tissue Engineering, 13(8), 2007 

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    Flexible Data Acquisition and Analysis

    Combine Radnoti's crystal clear borosilicate glassware with the precision of the PowerLab and LabChart to create experiments you control; from tissue to analysis.

     

    All your analysis in one place

    LabChart software is designed specifically for life science data and provides up to 32 channels for data display and analysis options that are powerful and easy to use. With auto-recognition of ADI and LabChart Compatible hardware, multi-window views, one touch recording, simultaneous recording from multiple devices, specialized preconfigured settings, easy sharing options and an interface that can be customized to show only the features you want to use.

    Related Add-Ons

    Dose Response

    The Dose Response Software Module allows analysis and graphical display of dose response type data recorded in LabChart.

    Event Manager

    The Event Manager Add-On for LabChart monitors incoming signals, detects user-defined events, and performs associated user-defined actions.

    Peak Analysis

    The Peak Analysis Module for LabChart provides automatic detection and analysis of multiple, non-overlapping, signal peaks.

    HRV

    The Heart Rate Variability (HRV) Module for LabChart analyzes beat-to-beat interval variation in ECG recordings or arterial pulse signals.

    ECG Analysis

    The ECG (EKG) Analysis Module for LabChart automatically detects and reports PQRST onset, amplitude and intervals in real time, or after recording.

    Blood Pressure

    The Blood Pressure Module for LabChart acts as a blood pressure graphing, monitoring & tracking software, automatically reporting cardiovascular parameters from arterial or ventricular pressure signals.