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Millar for Research - exclusively available from ADInstruments

Millar Mikro-tip catheters provide accurate and sensitive measurement of pressure parameters, whether you are investigating airway pressure, spinal pressure or one of the many cardiovascular pressures. ADInstruments Mikro-tip Pressure Volume System combines Millar’s highly sensitive catheters with the integrity of PowerLab data acquisition and LabChart data analysis software to help you measure complete cardiac function - LabChart's PV Loop module is purpose-built for the analysis of in vivo ventricular pressure-volume data in small and large mammals and includes workflows to guide you through each step of the calibration process. And with more than 4,000 citations in peer-reviewed journals, you can be sure you’ll get results you can trust. Non-repairable discount options are available. Contact us to find out more and if this is the right option for you.

Watch Webinar:

Understanding Ventricular Pressure-Volume Catheter Calibrations and Experimental Design

With Dr. Dimitros Georgakopoulos - an expert in the theory, history and application of ventricular pressure-volume technology.

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Best practice tips:

Best Practice Tips for Millar Pressure and Pressure Volume Catheters

This guide is intended to provide you with a few best practice tips to help get you started with your Millar Mikro-Tip® catheters.

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Proven within the research community

Millar Mikro-tip catheters and the conductance method of calibration have been tested and validated as an accurate and trustworthy combination for research.

Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

Pacher et al.

Nature protocols 3.9 (2008): 1422-1434.

Left ventricular volume measurement in mice by conductance catheter: evaluation and optimization of calibration

Nielsen et al.

American Journal of Physiology-Heart and Circulatory Physiology 293.1 (2007): H534-H540.

Validation of Conductance Catheter System for Quantification of Murine Pressure-Volume Loops

Yang et al.

Investigative Surgery 14.6 (2001): 341-355.

Validation of Conductance Catheter System for Quantification of Murine Pressure-Volume Loops

Yang et al.

Investigative Surgery 14.6 (2001): 341-355.

Does volume catheter parallel conductance vary during a cardiac cycle?

Lankford et al.

American Journal of Physiology - Heart and Circulatory Physiology 258.6 (1990): H1933-H1942.

Great science from trusted technology

There are many high impact publications citing ADInstruments and Millar equipment - we chose a few of our favorite ground-breaking studies.

 
  • Targeting Extracellular DNA to Deliver IGF-1 to the Injured Heart
    Raffay S. Khan, Mario D. Martinez,Jay C. Sy, Karl D. Pendergrass, Pao-lin Che, Milton E. Brown, E. Bernadette Cabigas, Madhuri Dasari, Niren Murthy & Michael E. Davis

    Khan et al utilized DNA released into the extracellular space during myocardial infarction to explore a potential method for targeting beneficial peptides to the damaged section of the myocardium. Their study conjugates IGF-1 to Hoechst, a cell stain that binds to double-stranded DNA, enabling specific delivery of the cardioprotective growth factor to the site of the damaged cells, helping to prevent apoptosis, promoting cell survival and proliferation, and reducing cardiac dysfunction following the MI.

    Khan, Raffay S., et al. "Targeting extracellular DNA to deliver IGF-1 to the injured heart." Scientific reports 4 (2014).

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  • Electrophysiological effects of right and left vagal nerve stimulation on the ventricular myocardium
    Kentaro Yamakawa , Eileen L. So , Pradeep S. Rajendran , Jonathan D. Hoang , Nupur Makkar , Aman Mahajan , Kalyanam Shivkumar , Marmar Vaseghi

    Yamakawa et al investigated the regional ventricular electrophysical effects of vagal nerve stimulation - a therapy which has been suggested by prior studies to have potential as a cardioprotective intervention. They stimulated the left and right vagal nerve to understand effects on the right and left ventricles and to characterize how other hemodynamic properties were affected.

    Yamakawa, Kentaro, et al. "Electrophysiological effects of right and left vagal nerve stimulation on the ventricular myocardium." American Journal of Physiology-Heart and Circulatory Physiology 307.5 (2014): H722-H731.

    Read More

  • Resistin-like Molecule Alpha in Allergen-induced Pulmonary Vascular Remodeling
    Chunling Fan, Lucas W. Meuchel, Qingning Su, Daniel J. Angelini, Ailan Zhang, Chris Cheadle, Irina Kolosolva, Oleg D. Makarevich, Kazuyo Yamaji-Kegan, Marc E. Rothenberg, and Roger A. Johns

    Fan et al used genetic knockout mice to understand the role of Resistin-like molecule alpha in pulmonary vascular remodelling and inflammation caused by an immune response. They measured effects of lung immune response stimulation on right ventricular systolic pressure and pulmonary pressure, among other parameters.

    Fan, Chunling, et al. "Resistin-like Molecule Alpha in Allergen-induced Pulmonary Vascular Remodeling." American journal of respiratory cell and molecular biology ja (2015).

    Read More

Millar Transducers

Pressure Catheters
 

Millar Mikro-Tip® pressure catheters provide an ideal solution for measuring highly accurate pressures.

Electrophysiology Catheters
 

Used to perform standard electrophysiology studies by applying pacing and recording protocols from inside the heart (intracardiac) or through the esophagus (transesophageal) to determine electrical properties of the atrium and the ventricle.

Large Animal PV Catheters
 

The Ventri-Cath PV catheters are multi-segment pressure-volume (PV) catheters for complete cardiac function assessment in continuously beating, intact hearts of large animals (including dog, pig and sheep).

Small Animal PV Catheters
 

Millar ultra-miniature pressure-volume (PV) catheters have revolutionized cardiovascular research as their small size means that they can be inserted directly into the heart with virtually no effect on the normal functioning of the heart.

Non Invasive Pulse Tonometer

The Non Invasive Pulse Tonometer is a hand-held wand probe equipped with a Mikro-Tip pressure sensor at the tip, designed for non-invasive recording of pulse pressure wave contours.

Rat PV Catheters
 

These ultra-miniature Polyimide Nylon catheters are capable of measuring both ventricular pressure and volume simultaneously and continuously from the intact beating hearts of rats and mice.

Mouse PV Catheters
 

These ultra-miniature catheters are capable of measuring left ventricular pressure and volume simultaneously and continuously from the intact, beating hearts of mice.

 

Millar Complete Systems and Instruments

MPVS Ultra Foundation Systems

The MPVS Ultra Foundation Systems are configured for measurement of ventricular pressure and volume in small through to large animal hearts, using an appropriate PV catheter.

MPVS Ultra PV Unit (large and small animals)

The MPVS Ultra Pressure-Volume (PV) Unit utilizes state-of-the-art technology in the measurement of ventricular pressure and volume in small (mice, rats) through to large animals (dog, sheep, pig).

Pressure Signal Conditioner
 

The Pressure Signal Conditioner is a two-channel amplifier/interface unit for connecting one or two Millar Mikro-Tip catheters.

MPVS Ultra Single Segment PV Unit

The MPVS Ultra Single Segment Pressure-Volume (PV) Unit utilizes state-of-the-art technology in the measurement of ventricular pressure and volume in mice and rats.

Accessories and Parts

Catheter Interface Cables
 

A complete range of catheter interface cables.

Pressure Control Unit
 

A passive interface between catheter and a strain gauge amplifier, connects to any Bridge Amp with supplied monitor cable.

MPVS Ultra Cable Packs
 

MPVS Ultra Cable Packs for connecting single pressure, dual pressure and/or multi-segmented pressure-volume catheters to an MPVS Ultra Pressure-Volume (PV) Unit, or the outputs of the MPVS Ultra PV Unit to a PowerLab.​

Volume Calibration Cuvettes

Volume Calibration Cuvettes are used to calibrate any of the mouse or rat Single Segment Pressure-Volume Catheters when used with the MPVS Ultra Single Segment Pressure-Volume Unit.

Rho Calibration Cuvette
 

The Rho Calibration Cuvette is used to calibrate Pressure-Volume catheters using the MPVS Ultra Pressure-Volume unit (large and small animals).

PV Extension Cable (Ventri-Cath to MPVS Ultra, 10ft)

10ft extension cable designed to connect the MPVS-Ultra Pressure-Volume Unit (large and small animals) to the Ventri-Cath series animal pressure-volume (PV) catheters (large animal, small animal, mice and rats).

EPR Catheter Interface Cable (5 ft)

Connects Millar Electrophysiology Catheters to any ADInstruments Bio Amp, or directly to the Octal Bio Amp.

 

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If you’d like to speak to someone immediately, office contact information is available from the contact page.

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