Phosphodiesterase 3A and Arterial Hypertension
Background: High blood pressure is the primary risk factor for cardiovascular death worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt-resistant essential hypertension and causes death by stroke…
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice
Nitrosative stress drives heart failure with preserved ejection fraction
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
Abstract Oxidative stress plays an important role in the pathogenesis of many disease states. In the heart, reactive oxygen species are linked with cardiac ischemia/reperfusion injury, hypertrophy, and heart failure. While this correlation between ROS and car…
Single-source PPG-based local pulse wave velocity measurement: a potential cuffless blood pressure estimation technique
Abstract Objective: A novel photoplethysmograph probe employing dual photodiodes excited using a single infrared light source was developed for local pulse wave velocity (PWV) measurement. The potenti…
A Magnetic Plethysmograph Probe for Local Pulse Wave Velocity Measurement
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Abstract Patients with short QT syndrome (SQTS) may present with syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding cation channels, explain <25% of SQTS cases. Here we identify a missense mutation in the ani…
Mammalian γ2 AMPK regulates intrinsic heart rate
Abstract AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding ade…
A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
Abstract The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connect…
DOI: 10.1038/ncomms13035
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
Abstract Atrial fibrillation (AF), the most common arrhythmia, is a growing epidemic with substantial morbidity and economic burden. Mechanisms underlying vulnerability to AF remain poorly understood, which contributes t…
DOI: 10.1038/ncomms11303