Induced blood flow oscillations at 0.1 Hz protects oxygenation of severely ischemic tissue in humans
2024
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Austin Davis, Nasrul Bhuiyan, Benjamin McIntyre, Viet Dinh, Caroline Rickards
·
Journal of Applied Physiology
Abstract
We investigated the effects of induced 10-s (0.1 Hz) oscillations in blood flow on forearm tissue oxygenation during severe ischemia. Intermittent inflation of bilateral thigh cuffs was used as a clinically applicable method to drive blood flow oscillations. In support of our hypothesis, 0.1 Hz oscillations in blood flow blunted reductions in forearm tissue oxygenation. These results further support the potential use of oscillatory hemodynamics as a therapeutic intervention for ischemic conditions.
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Publication Details
- Journal
- Journal of Applied Physiology
- Volume
- 137
- Issue
- 5
- Pages
- 1243-1256
- Publisher
- American Physiological Society
- ISSN
- 8750-7587, 1522-1601