A soft multimodal optoelectronic array interface for multiparametric mapping of heart function in vivo
Multiparametric investigation of cardiac physiology is crucial for the diagnosis and therapy of heart disease. However, no method exists to simultaneously map multiple parameters that govern cardiac (patho)physiology from beating hearts in vivo. Here, we prese…
AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models
Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure
Abstract Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across developmental lineages. Here, we engineer barcoded induced pluripotent stem cells to generate an…
Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine
Abstract It is unclear whether hallucinogenic tryptamine derivatives namely N , N -dimethyl-tryptamine (DMT) and 5-methoxy-…
cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling
Fluid shear stress (FSS) from blood flow sensed by vascular endothelial cells (ECs) determines vessel behavior, but regulatory mechanisms are only partially understood. We used cell state transition assessment and regulation (cSTAR), a powerful computational m…
HCN4 channels sense temperature and determine heart rate responses to heat
Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies
Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy
Abstract Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergot…