A neuronal architecture underlying autonomic dysreflexia
Spatiotemporal control of neutrophil fate to tune inflammation and repair for myocardial infarction therapy
Persistence of post-stress blood pressure elevation requires activation of astrocytes
Abstract The reflexive excitation of the sympathetic nervous system in response to psychological stress leads to elevated blood pressure, a condition that persists even after the stress has been alleviated. This sustained increase in blood pressure, which may…
Acetazolamide and topiramate lower intracranial pressure through differential mechanisms: The effect of acute and chronic administration
Abstract Background and Purpose Diseases of raised intracranial pressure (ICP) cause severe morbidity and mortality. Multiple drugs are utilised to lower ICP including acetazolamide and topiramate. However, the evidence for their use is unclear. We aimed to…
DOI: 10.1111/bph.16213
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
Long-term monitoring of intracranial pressure in freely-moving rats; impact of different physiological states
Abstract Background Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. There is limited insight into the regulatory mechanisms of ICP under physiological conditions, and consequent…
Correction of medication nonadherence results in better seizure outcomes than dose escalation in a novel preclinical epilepsy model of adherence
Summary Objective Medication nonadherence directly contributes to poor seizure control. A lack of emphasis on correcting poor adherence and failures in patient adherence can result in unwarranted alterations to a patient's drug regimen. We have modeled nonad…
DOI: 10.1111/epi.14655
Hypertensive Response to Ischemic Stroke in the Normotensive Wistar Rat
Background and Purpose— Over 80% of ischemic stroke patients show an abrupt increase in arterial blood pressure in the hours and days following ischemic stroke. Whether this poststroke hypertension is beneficial or harmful remains controversial an…
Recording of intracranial pressure in conscious rats via telemetry
Although cerebral perfusion pressure (CPP) is known to be fundamental in the control of normal brain function, there have been no previous long-term measurements in animal models. The aim of this study was to explore the stability and viability of long-term re…
Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats
Expansion of physiological knowledge increasingly requires examination of processes in the normal, conscious state. The current study describes a novel approach combining surgical implantation of radio-telemeters with vascular access ports (VAPs) to allow repe…