Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice
Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
Abstract Heart rate is under the precise control of the autonomic nervous system. However, the wiring of peripheral neural circuits that regulate heart rate is poorly understood. Here, we develop a clearing-imaging-analysis pipeline to visua…
Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
Abstract Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing…
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
Abstract Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO 2 and pH homeostasis in the brain. CO 2…
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission
Abstract Shrm4, a protein expressed only in polarized tissues, is encoded by theKIAA1202gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we rep…
DOI: 10.1038/ncomms14536
A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication
Abstract The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connect…
DOI: 10.1038/ncomms13035