Cardiac parasympathetic denervation reduces hypoxic tachycardia, baroreflex sensitivity and heart rate variability in humans
Optimising CPAP and oxygen levels to support spontaneous breathing in preterm rabbits
Abstract Background Very preterm infants often require respiratory support after birth with current recommendations suggesting the use of continuous positive airway pressure (C…
Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine
Abstract Acute respiratory failure can cause profound hypoxaemia that leads to organ injury or death within minutes. When conventional interventions are ineffective, the intravenous administration of oxygen can rescue patients from severe hy…
Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension
Background: Exertional intolerance is a limiting and often crippling symptom in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Traditionally the pathogenesis has been attributed to central factors, including ventilation/perfu…
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension Via mTORC1 Signaling
Abstract Rationale Vascular remodeling, including smooth muscle cell hypertrophy and proliferation, is the key pathological feature of pulmonary arterial hypertension (PAH). Prostaglandin I2 analogs…
D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels
Abstract Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO 2 and pH homeostasis in the brain. CO 2…
Fish optimize sensing and respiration during undulatory swimming
Abstract Previous work in fishes considers undulation as a means of propulsion without addressing how it may affect other functions such as sensing and respiration. Here we show that undulation can optimize propulsion, flow sensing and respiration concurrentl…
DOI: 10.1038/ncomms11044