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Pharmacology

Overview

This collection explores pharmacological phenomena such as agonists, antagonists, and dose-response relationships using a variety of different tissue preparations.

Lessons

Vascular Smooth Muscle

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Lesson Overview:

In this lab students will use arterial rings from a pig coronary artery to explore some drug effects. Arterial rings can be used to demonstrate classical responses to autonomic drugs on vascular smooth muscle. Arterial rings can also be used to show the recently-discovered role of the endothelium in modulating vascular responses.

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Vascular Resistance

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Lesson Overview:

In this lab students perfuse the isolated hindquarters of a rat at a constant flow. From the changes in pressure required to maintain this flow, the vascular resistance is recorded.

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Unstimulated Rat Vas Deferens

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Lesson Overview:

In this lab students use an isolated rat vas deferens to investigate the effects of alpha adrenergic receptor agonists and antagonists, and drugs that affect the amount of norepinephrine in the synaptic cleft.

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Unstimulated Ileum

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Lesson Overview:

In this lab students examine the effects of a variety of drugs on the unstimulated guinea pig ileum preparation. Students also examine the effects of two mystery drugs and determine their mechanism of action.

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Toad Rectus Abdominis

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Lesson Overview:

In this lab students use an isolated toad rectus abdominis muscle to investigate the effects of tubocurarine and suxamethonium on muscle contraction stimulated by acetylcholine application.

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Stimulated Rat Vas Deferens

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Lesson Overview:

In this lab students use a stimulated rat vas deferens to study drugs that act presynaptically and test the effects of these drugs on synaptic transmission. They also investigate the effects of a range of adrenoceptor agonists and antagonists.

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Stimulated Ileum

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Lesson Overview:

In this lab students will use a stimulated guinea pig ileum preparation to investigate how codeine and other drugs affect gastrointestinal motility.

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Mammalian Uterus

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Lesson Overview:

In this lab students examine the effects of a variety of drugs (oxytocine, epinephrine, high potassium solution, salbutamol, and propanolol) on a stimulated mammalian uterus preparation.

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Mammalian Jejunum

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Lesson Overview:

In this lab students will apply repetitive electrical stimulation to the sympathetic nerves of the isolated rabbit jejunum. This electrical stimulation inhibits rhythmic output from the enteric nerve plexuses, which in turn leads to relaxation of the intestine and reduced gastrointestinal motility. They will also investigate how the drug guanethidine prevents the release of norepinephrine from sympathetic ("adrenergic") nerve terminals.

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Mammalian Heart

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Lesson Overview:

In this lab students use an isolated rabbit heart to investigate the effects of selected neurotransmitters and drugs on heart rate and the force of contraction.

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Mammalian Diaphragm

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Lesson Overview:

In this lab students use an isolated phrenic-innervated diaphragm muscle preparation to investigate how the drugs suxamethonium, tubocurarine, and edrophonium affect neuromuscular transmission.

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Mammalian Atria

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Lesson Overview:

In this lab students use a guinea pig atria to examine how certain drugs affect the frequency and strength of myocardial contraction.

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Chick Biventer Cervicis

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Lesson Overview:

In this lab students use the isolated biventer cervicis muscle from a chick to investigate how the curare poison affects muscle contraction, and which drugs may work as an antidote to curare.

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Airways Resistance

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Lesson Overview:

Students use a guinea pig trachea dissection to simulate asthma, and measure the effects of histamine and acetylcholine on airway contraction. Students also observe the effects of drugs used to treat asthma, such as salbutamol and theophylline, and their interaction.

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