Reining chaos to save lives
Dr. Manasi Nandi Ph.D. is a cardiovascular pharmacologist and a Senior Lecturer in Integrative Pharmacology at King’s College London. Manasi’s particular research interest is in sepsis and septic shock, and the cardiovascular dysregulation that occurs in those patients. She is working on a groundbreaking interdisciplinary project with mathematician Professor Philip Aston from Surrey University, that aims to detect the onset of disease earlier. In the setting of critical care and sepsis, this could be life saving.
Sepsis - A Global Issue
The World Health Organisation estimates that each year:
Hundreds of millions
Sepsis: the problem and the challenge.
Using LabChart to extract high fidelity waveforms
Manasi uses ADInstruments’ LabChart software to extract the high fidelity cardiovascular waveforms that are used to build the attractor. The waveforms can come from blood pressure, ECG, or pulse oximetry data. She says,” I use LabChart for a variety of applications in my work. The software allows you to take averages of routine signals like systolic and diastolic pressure easily. But at the same time, in the background, it’s collecting really high fidelity data and sampling it at a thousand data points per second or a thousand Hertz. It means that I can go ahead and extract that big data out of LabChart and feed it into our new bit of coding, which then transforms it into our attractor. So LabChart allows me to do both a conventional analysis but also gives me the raw data to feed into the new system to do the new analysis.”
“When we look at our human volunteers, we often rig them up with lots of different devices on them. So we’ll be measuring a fingertip blood pressure reading, we’ll also be getting ECG monitoring from them at the same time. And it means we’ve got a continuous stream of data from that individual that tells us a lot about their cardiovascular system.”