In this lab, learners perfuse the isolated hindquarters of a rat at a constant flow. From the changes in pressure required to maintain this flow, the vascular resistance is recorded. While many drugs have an effect on blood pressure, this can be due to a primary effect on the heart (changing flow) or on the vascular bed (changing resistance). To clearly define the site of action in the cardiovascular system, it is often necessary to use a simplified preparation such as the rat hindquarters.
Download the lesson