Middle Cerebral Artery Occlusion (MCAO) models are typically used when studying the effects or treatments of a stroke.
It is possible to measure the blood flow in the brain in these models with the IN191 Blood Flow Meter, suitable probe and a PowerLab. We generally
recommend the MNP100XP needle probe for MCAO measurements. and there is an option to make
a shortened version of the shaft (10mm) so it would fit perfectly
within the MH-5 guides shown below.
With regards to the placement of
the probe, it can help to use small holders. These miniature plastic holders are specially designed
for use with a shortened version of the MNP100XP needle probe for the
measurement of local cerebral cortex perfusion in this model. The holders can be directly attached to bone (skull) using
cyanoacrylate or rapid-setting epoxy glues and provide a very secure
hold for the probe.
The probes are factory calibrated, but can also be
calibrated before each experiment if required.