In this webinar Dr. Senthilkumari Srinivasan discusses Ocular Pharmacology with specific focus on the Organ-Cultured Anterior Segment (OCAS) model using different animal species.
Key Learning Objectives:
- An overview of Organ-cultured Anterior Segment (OCAS) Model using diﬀerent animal species
- Demonstration of Human Organ-Cultured Anterior Segment
- (HOCAS) Ex vivo experimental set-up
- Application of HOCAS in anti-glaucoma drug screening, induction of diseased condition and evaluation of cell-based therapy-our experiences
- Limitations of OCAS
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About the speaker:
Dr. Senthilkumari Srinivasan
Scientist (RS3) Dept. of Ocular Pharmacology
Aravind Medical Research Foundation (AMRF)
Dr. Senthilkumari has received her Ph.D. in Ocular Pharmacology from Dr. RP Center for Ophthalmic Sciences, AIIMS, New Delhi in 2008. Her research focuses on understanding the molecular mechanism(s) involved in the pathogenesis and identifying drug targets for the “silent sight killer – Glaucoma especially POAG and steroid-induced glaucoma”. Through DBT-CREST Award (2011-12), she has received an extensive training and hands-on experience on organ-cultured anterior segment at Dr. Kaufman’s lab, University of Wisconsin, Madison, USA, and she established the human organ-cultured anterior segment (HOCAS) facility at AMRF. This ex vivo model system is the first of its kind in India which is utilized to determine the trabecular meshwork outflow facility responses to investigational drugs.