High-Impact Research Publications Using ADInstruments

Explore a curated selection of peer-reviewed research that utilizes ADInstruments products, from anatomy to zoology and across the life sciences.

Rearing in an enriched environment attenuated hyperactivity and inattention in the Spontaneously Hypertensive Rats, an animal model of Attention-Deficit Hyperactivity Disorder

2016 · C Botanas, H Lee, J de la Pena et al. · Physiology & Behavior
Area Animal > Telemetry Application EEG Signal EEG Product Biopotential Telemeter (ECG, EEG, EMG)

Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder, characterized by symptoms of hyperactivity, inattention, and impulsivity. It is commonly treated with psychostimulants that typically begins during childhood and lasts…

DOI: 10.1016/j.physbeh.2015.11.035

The Impact of Midcervical Contusion Injury on Diaphragm Muscle Function

2016 · S Alvarez-Argote, H Gransee, J Mora et al. · Journal of neurotrauma
Area Animal > Telemetry Signal EMG Product Dual Biopotential Telemeter (ECG, EEG and/or EMG)

Midcervical contusion injuries disrupt descending ipsilateral excitatory bulbospinal projections to phrenic motoneurons, compromising ventilation. We hypothesized that a unilateral contusion injury at C3 versus C5 would differentially impact phrenic activity r…

DOI: 10.1089/neu.2015.4054

Hemodynamic and neural responses to renal denervation of the nerve to the clipped kidney by cryoablation in two-kidney, one-clip hypertensive rats

2016 · N Rossi, R Pajewski, H Chen et al. · American journal of physiology.Regulatory, integrative and comparative physiology
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure

Renal artery stenosis is increasing in prevalence. Angioplasty plus stenting has not proven to be better than medical management. There has been a reluctance to use available denervation methodologies in this condition. We studied conscious, chronically instru…

DOI: 10.1152/ajpregu.00331.2015

Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation

2016 · E Moya, P Arias, C Varela et al. · Oxidative medicine and cellular longevity
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure Product Pressure Telemeter

Oxidative stress is involved in the development of carotid body (CB) chemosensory potentiation and systemic hypertension induced by chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea. We tested whether peroxynitrite (ONOO(-)), a hi…

DOI: 10.1155/2016/9802136

Milk Collected at Night Induces Sedative and Anxiolytic-Like Effects and Augments Pentobarbital-Induced Sleeping Behavior in Mice

2015 · I Pena, E Hong, J de la Pena et al. · Journal of medicinal food
Area Animal > Telemetry Application EEG Signal EEG Product Biopotential Telemeter (ECG, EEG, EMG)

Milk has long been known and used to promote sleep. The sleep-promoting effect of milk has been attributed to its psychological associations (i.e., the memory of a mother giving milk at bedtime) and its rich store of sleep-promoting constituents (e.g., tryptop…

DOI: 10.1089/jmf.2015.3448

Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus

2015 · M Read, J Harrison, D Kerr et al. · British journal of pharmacology
Area Animal > Telemetry Application ECG Application EEG Signal ECG Signal EEG Product Dual Biopotential Telemeter (ECG, EEG and/or EMG)

BACKGROUND AND PURPOSE: Status epilepticus is increasingly associated with cardiac injury in both clinical and animal studies. The current study examined ECG activity for up to 48 h following kainic acid (KA) seizure induction and compared the potential of ate…

DOI: 10.1111/bph.13132

Ursolic acid enhances pentobarbital-induced sleeping behaviors via GABAergic neurotransmission in mice

2015 · S Jeon, H Park, Q Gao et al. · European journal of pharmacology
Area Animal > Telemetry Application EEG Signal EEG Product Biopotential Telemeter (ECG, EEG, EMG)

Prunella vulgaris is widely used as a herbal medicine for cancers, inflammatory diseases, and other infections. Although it has long been used, few studies have examined its effects on central nervous system function. Here, we first observed that ethanolic ext…

DOI: 10.1016/j.ejphar.2015.06.037

Direct conscious telemetry recordings demonstrate increased renal sympathetic nerve activity in rats with chronic kidney disease

2015 · I Salman, Sarma Kandukuri, J Harrison et al. · Frontiers in physiology
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure Product SNA and Pressure Telemeter

Chronic kidney disease (CKD) is associated with sympathetic hyperactivity and impaired blood pressure control reflex responses, yet direct evidence demonstrating these features of autonomic dysfunction in conscious animals is still lacking. Here we measured re…

DOI: 10.3389/fphys.2015.00218

The new nitric oxide donor cyclohexane nitrate induces vasorelaxation, hypotension, and antihypertensive effects via NO/cGMP/PKG pathway

2015 · Ld Mendes-Junior, D Guimaraes, D Gadelha et al. · Frontiers in physiology
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure Product Pressure Telemeter

We investigated the cardiovascular effects induced by the nitric oxide donor Cyclohexane Nitrate (HEX). Vasodilatation, NO release and the effects of acute or sub-chronic treatment with HEX on cardiovascular parameters were evaluated. HEX induced endothelium-i…

DOI: 10.3389/fphys.2015.00243