High-Impact Research Publications Using ADInstruments

Explore a curated selection of peer-reviewed research that utilizes ADInstruments products, from anatomy to zoology and across the life sciences.

Recording sympathetic nerve activity chronically in rats: surgery techniques, assessment of nerve activity, and quantification

2013 · S Stocker, M Muntzel · American journal of physiology.Heart and circulatory physiology
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure Product SNA and Pressure Telemeter

The sympathetic nervous system plays a pivotal role in homeostasis through its direct innervation and functional impact on a variety of end organs. In rats, a number of methods are available to assess sympathetic nervous system function. Traditionally, direct…

DOI: 10.1152/ajpheart.00173.2013

Effect of insular cortex inactivation on autonomic and behavioral responses to acute hypoxia in conscious rats

2013 · J Casanova, M Contreras, E Moya et al. · Behavioural brain research
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure

The present work was aimed to evaluate the contribution of interoception to the autonomic and behavioral responses to hypoxia. To address this issue, we studied whether the inactivation of the primary interoceptive posterior insular cortex (pIC) may disrupt th…

DOI: 10.1016/j.bbr.2013.07.015

Role of brain nitric oxide in the cardiovascular control of bullfrogs

2013 · L Zena, L Gargaglioni, K Bicego · Comparative biochemistry and physiology.Part A, Molecular & integrative physiology
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure

The goal of the present study was to determine if nitric oxide (NO) acting on the brain of bullfrog (Lithobates catesbeianus) is involved in arterial pressure and heart rate (HR) control by influencing sympathetic activity. We investigated the effect of intrac…

DOI: 10.1016/j.cbpa.2013.03.020

Telemetry-based oxygen sensor for continuous monitoring of kidney oxygenation in conscious rats

2013 · M Koeners, C Ow, D Russell et al. · American journal of physiology.Renal physiology
Area Animal > Telemetry Product Tissue Oxygen Telemeter

The precise roles of hypoxia in the initiation and progression of kidney disease remain unresolved. A major technical limitation has been the absence of methods allowing long-term measurement of kidney tissue oxygen tension (Po(2)) in unrestrained animals. We…

DOI: 10.1152/ajprenal.00662.2012

Necrotic trophoblast debris increases blood pressure during pregnancy

2013 · S Lau, C Barrett, S Guild et al. · Journal of reproductive immunology
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure

Preeclampsia is a major disease of human pregnancy characterised by hypertension and proteinuria. These signs are preceded by systemic maternal endothelial dysfunction. Hypertension in preeclampsia appears to be triggered by a placental factor, which leads to…

DOI: 10.1016/j.jri.2012.12.005

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension

2013 · F McBryde, A Abdala, E Hendy et al. · Nature communications
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure

In the spontaneously hypertensive (SH) rat, hyperoxic inactivation of the carotid body (CB) produces a rapid and pronounced fall in both arterial pressure and renal sympathetic nerve activity (RSA). Here we show that CB de-afferentation through carotid sinus n…

DOI: 10.1038/ncomms3395

Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure following myocardial infarction in rats

2013 · N Marina, F Tang, M Figueiredo et al. · Basic research in cardiology
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure

Heart failure may lead to hypoperfusion and hypooxygenation of tissues and this is often exacerbated by central and obstructive sleep apnoeas associated with recurrent episodes of systemic hypoxia which triggers release of ATP within the CNS circuits controlli…

DOI: 10.1007/s00395-012-0317-x

Cafeteria diet increases fat mass and chronically elevates lumbar sympathetic nerve activity in rats

2012 · M Muntzel, O Al-Naimi, A Barclay et al. · Hypertension (Dallas, Tex.: 1979)
Area Animal > Telemetry

Obesity causes sympathetic activation that promotes atherosclerosis, end-organ damage, and hypertension. Because high-fat induced weight gain in rats elevates plasma leptin at 1 to 3 days after the onset of calorie-dense diets, we hypothesized that diet-induce…

DOI: 10.1161/HYPERTENSIONAHA.112.194886

Effects of sex and ovarian hormones on the initial renal sympathetic nerve activity response to myocardial infarction

2012 · M Pinkham, S Guild, S Malpas et al. · Experimental physiology
Area Animal > Telemetry

The physiological mechanisms contributing to sex differences following myocardial infarction (MI) are poorly understood. Given the strong relationship between sympathetic nerve activity (SNA) and outcome, we hypothesized there may be a sex difference in SNA re…

DOI: 10.1113/expphysiol.2012.065615

NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension

2012 · Z Ye, D Li, H Byun et al. · The Journal of neuroscience : the official journal of the Society for Neuroscience
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure

Hypertension is a major risk factor for coronary artery disease, stroke, and kidney failure. However, the etiology of hypertension in most patients is poorly understood. Increased sympathetic drive emanating from the hypothalamic paraventricular nucleus (PVN)…

DOI: 10.1523/JNEUROSCI.1346-12.2012