High-Impact Research Publications Using ADInstruments

Explore a curated selection of peer-reviewed research that utilizes ADInstruments products, from anatomy to zoology and across the life sciences.

Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat

2017 · C Bussey, R Lamberts · Physiological reports
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure Product Pressure Telemeter

Diabetic patients have increased cardiac complications during surgery, possibly due to impaired autonomic regulation. Anesthesia lowers blood pressure and heart rate (HR), whereas surgical intervention has opposing effects. The interaction of anesthesia and su…

Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis

2017 · Victor Jeger, Mattia Arrigo, Florian Hildenbrand et al. · Intensive Care Med Exp
Area Animal > Telemetry Application ECG Signal ECG Product Biopotential Telemeter (ECG, EEG, EMG)

Background Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs pr…

High Thoracic Contusion Model for the Investigation of Cardiovascular Function after Spinal Cord Injury

2017 · J Squair, C West, D Popok et al. · Journal of neurotrauma
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure Product SNA and Pressure Telemeter

Cardiovascular disease is the leading cause of death for individuals with spinal cord injury (SCI). Because of a lack of a standardized and accessible animal model for cardiovascular disease after SCI, few laboratories have conducted pre-clinical trials aimed…

DOI: 10.1089/neu.2016.4518

Src Kinases Regulate Glutamatergic Input to Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension

2017 · X Qiao, J Zhou, D Li et al. · Hypertension (Dallas, Tex.: 1979)
Area Animal > Telemetry Application Blood Pressure Product Blood Pressure Product Pressure Telemeter

The elevated sympathetic outflow associated with hypertension is maintained by increased N-methyl-d-aspartate receptor (NMDAR) activity in the paraventricular nucleus (PVN) of the hypothalamus. Synaptic NMDAR activity is tightly regulated by protein kinases, i…

A tryptic hydrolysate from bovine milk alphas1-casein enhances pentobarbital-induced sleep in mice via the GABAA receptor

2016 · I Pena, H Kim, J de la Pena et al. · Behavioural brain research
Area Animal > Telemetry Application EEG Signal EEG Product Biopotential Telemeter (ECG, EEG, EMG)

Studies have shown that enzymatic hydrolysis of casein, the primary protein component of cow's milk, produces peptides with various biological activities, and some of these peptides may have sleep-promoting effects. In the present study, we evaluated the sedat…

DOI: 10.1016/j.bbr.2016.07.013

Multiscale entropy analysis of heart rate variability in heart failure, hypertensive, and sinoaortic-denervated rats: classical and refined approaches

2016 · L Silva, R Lataro, J Castania et al. · American journal of physiology.Regulatory, integrative and comparative physiology
Area Animal > Telemetry Application ECG Signal ECG Product Biopotential Telemeter (ECG, EEG, EMG)

The analysis of heart rate variability (HRV) by nonlinear methods has been gaining increasing interest due to their ability to quantify the complexity of cardiovascular regulation. In this study, multiscale entropy (MSE) and refined MSE (RMSE) were applied to…

DOI: 10.1152/ajpregu.00076.2016