The goal of a saline bolus is to achieve a sudden increase in measured volume while maintaining a stable pressure signal. This provides the data required by the software to eliminate the parallel volume of the myocardium. The response to the bolus should look like below:
A mixture of 15-30% hypertonic saline solution is typically injected through the jugular vein. The left jugular is suggested for ease of surgery when collecting PV data from the left ventricle.
A mixture of 15-30% hypertonic saline solution is typically injected through the jugular vein. The left jugular is suggested for ease of surgery when collecting PV data from the left ventricle.
- Typical injection ranges for mice are 5-10 µL
- Typical injection ranges for rats are 20-40 µL