To support our customers performing cardiovascular research, we designed the compact Rodent Langendorff Apparatus.
This design prioritizes features that improve data quality, ease of use, and modularity to suit users with simple and complex experimental designs.
The modular construction suits researchers with various experimental needs, a compact surface area minimizes bench space requirements, and maintenance is streamlined with high-quality materials and autoclavable glassware. And with the addition of the Direct Perfusion Core, researchers can measure data from closer to the heart.
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Modularity
Commercially available Langendorff systems generally fall into one of two categories: compact or complex. Both approaches have their advantages.
A compact Langendorff Apparatus is made from plastic, or acrylic pieces, which fit together into one solid unit after assembly. Once assembled, the apparatus cannot be altered.
With a more complex Langendorff, the researcher can customize the system to their requirements. Each apparatus component attaches separately to a support stand, allowing the researcher to customize configuration and height.
Many experimental designs do not require this amount of customization. To address the gap between these two designs, the ADInstruments Rodent Langendorff Apparatus incorporates elements from both for a modular yet compact solution.
“Just like the PanLab it is ready to be used out of the box, it is compact. But unlike the PanLab it is modular: it can be tailored to your specific needs.”
- Dr Melanie White
This design enables researchers to do their best work and will grow with their experimental needs. Researchers can begin with a simplified apparatus, such as a single reservoir design, and expand the same apparatus with optional components, such as adding recirculation. Other easy customization includes hanging the heart on the left or right side of the apparatus.
Modularity also reduces the cost of replacement in the case of damage. In the case of most compact, static Langendorffs, researchers must repurchase the entire apparatus if any piece becomes damaged. Should the need arise, any individual component of the ADInstruments Rodent Langendorff is replaceable.
High-quality materials
The ADInstruments Rodent Langendorff is made with high-quality borosilicate glassware. All of the glassware is double-walled, and heated water maintains the temperature of the apparatus. Glass is a superior material to acrylic or plastic for several reasons; it increases visibility of the perfusate pathway, it doesn’t crack or yellow with time, and it is chemically inert. Yellowing, stainless steel components, and opaque components that are part of the circuit would prevent you from seeing bubbles or particulate matter that might be present in your perfusion circuit.
Maintaining your Langendorff
As retrograde perfusion can often be messy, the ADInstruments Rodent Langendorff Apparatus has features designed to improve cleanliness.
The Stand Base Spill Tray reduces the need to wipe down your lab bench. Designed to be compatible with all Radnoti stand bases or support rods, the slopped surface of this tray guides liquid runoff to a drain connected to rubber tubing.
Radnoti glassware is also autoclavable. The modularity of the apparatus means that researchers can autoclave each glass component individually, ensuring it is thoroughly clean.
ADInstruments is dedicated to making science easier and innovating the technology researchers rely on. The ADInstruments Rodent Langendorff Apparatus is our modular yet compact solution ideal for retrograde perfusion of isolated rodent hearts (mice, rats, guinea pigs, and small rabbits).
Our support team is passionate about research. Please contact your local representative if you have any questions about how to customize our products to fit your application.
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