Here at ADInstruments, we're lucky to be a part of a large and thriving research community. Join us in celebrating some of the incredible work published by that community in March.
CBD reshapes the gut microbiome to promote endurance exercise in mice
Published in Experimental & Molecular Medicine
In this article, Chen et al., investigate how CBD influences exercise performance and muscle function. CBD significantly increased treadmill running endurance in mice by promoting a shift from glycolytic to oxidative muscle fibers. This effect was linked to enhanced mitochondrial biogenesis and activation of key metabolic pathways involving AMPK, CREB, and PGC-1α. Notably, CBD also altered the gut microbiome, increasing the abundance of the KBP-1 strain of Bifidobacterium animalis bacteria. When administered separately, KBP-1 improved endurance performance, suggesting a direct role in metabolic adaptation. Antibiotic treatment negated the endurance benefits of CBD, further supporting the microbiome’s involvement.
Read more: https://doi.org/10.1038/s12276-025-01404-5
ADInstruments Products:
Excised gastrocnemius muscle tissue was tested in a Radnoti organ bath.
HCN4 channels sense temperature and determine heart rate responses to heat
Published in Nature Communications
In this study, Wu et al., investigate how hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (HCN4) responds to heat and influences heart rate regulation. Using computational modelling, site-directed mutagenesis, and mouse models, the team identified a critical motif (M407/Y409) on the S4-S5 linker of HCN4 essential for heat-induced activation of the cardiac pacemaker current. Mutation of this motif abolished not only heat responsiveness but also cAMP-mediated activation, revealing that thermal sensing is central to HCN4 function. The findings suggest that HCN4 channels play a fundamental role in coupling temperature changes to cardiac excitability.
Read more: https://doi.org/10.1038/s41467-025-57358-9
ADInstruments Products:
Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis
Published in Nature Communications
Heydemann et al., examine the long-term respiratory effects of SARS-CoV-2 infection in aged hamsters, focusing on lung regeneration over 112 days. While lung function impairments were severe during the acute phase, they persisted in the chronic phase, particularly after exercise. The team identified ongoing structural lung changes,
A respiratory gas analyzer was used to assess lung function non-invasively.
including sub-pleural and interstitial fibrosis and alveolar bronchiolization, which resemble those seen in long COVID patients. Transcriptomic analysis revealed prolonged pro-fibrotic changes and airway progenitor cell proliferation, suggesting potential long-term risks. The findings highlight this hamster model as a valuable tool for studying respiratory long COVID and its underlying mechanisms.
Read more: https://doi.org/10.1038/s41467-025-57267-x
ADInstruments Products:
Cardiac parasympathetic denervation reduces hypoxic tachycardia, baroreflex sensitivity and heart rate variability in humans
Published in Scientific Reports
In this article, Niewinski et al. investigate the effects of parasympathetic cardioneuroablation (PCNA) on heart rate reactivity to acute hypoxia in humans. Eleven patients undergoing PCNA for vasovagal syncope were examined before and after the procedure, with heart rate responses assessed using nitrogen gas administrations. PCNA led to partial cardiac parasympathetic denervation, significantly reducing heart rate response to hypoxia, and decreasing baroreflex sensitivity and heart rate variability. These changes highlight the critical role of parasympathetic control in heart rate regulation during hypoxia.
Read more: https://doi.org/10.1038/s41598-025-91214-6
ADInstruments Products:
Regulation of mammalian cellular metabolism by endogenous cyanide production
Published in Nature Metabolism
In this article, Zuhra et al. examine endogenously produced cyanide and its role as a regulatory molecule. The team found that cyanide is generated in various mammalian tissues, particularly within lysosomes, through a glycine-stimulated, peroxidase-dependent process. At low concentrations, cyanide enhances mitochondrial bioenergetics, cellular metabolism, and proliferation, while high concentrations impair cellular function. Cyanide also modifies proteins via S-cyanylation, influencing metabolic pathways and cellular signaling. Furthermore, low-dose cyanide supplementation showed cytoprotective effects under hypoxic conditions, suggesting a potential regulatory role akin to other gasotransmitters like nitric oxide and hydrogen sulfide. Conversely, excessive cyanide production, such as in nonketotic hyperglycinemia, was detrimental. These findings redefine cyanide as a physiological signaling molecule rather than merely a toxic compound.
Read more: https://doi.org/10.1038/s42255-025-01225-w
ADInstruments Products:
