High-Impact Research Publications Using ADInstruments

Explore a curated selection of peer-reviewed research that utilizes ADInstruments products, from anatomy to zoology and across the life sciences.

VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction

2024 · Harris Blankenship, Kelsey Carter, Kevin Pham et al. · Nature Communications
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Abstract Alzheimer’s disease (AD) patients exhibit neuropsychiatric symptoms that extend beyond classical cognitive deficits, suggesting involvement of subcortical areas. Here, we investigated the role of midbrain dopamine (DA) neurons in AD…

DOI: 10.1038/s41467-024-53891-1

Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist

2024 · Yuya Maruyama, Yusuke Ohsawa, Takayuki Suzuki et al. · Nature Communications
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Abstract Sphingosine 1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor, is required for lymphocyte trafficking, and is a promising therapeutic target in inflammatory diseases. Here, we synthesize a competitive S1PR1 antagonist, KSI-6666, that effec…

DOI: 10.1038/s41467-024-49893-8

Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity

2024 · Byron Hayes, Hae Choi, Abhay Rathore et al. · Science Immunology
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Urinary tract infections (UTIs) account for almost 25% of infections in women. Many are recurrent (rUTI), with patients frequently experiencing chronic pelvic pain and urinary frequency despite clearance of bacteriuria after antibiotics. To elucidate the basis…

DOI: 10.1126/sciimmunol.adi5578

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception

2024 · Julia Ojeda-Alonso, Laura Calvo-Enrique, Ricardo Paricio-Montesinos et al. · Nature Communications
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Abstract Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nocicept…

DOI: 10.1038/s41467-024-44845-8

Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice

2024 · Mylène Fefeu, Michael Blatzer, Anita Kneppers et al. · Nature Communications
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Abstract Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat mood disorders. The mechanisms of action include an increase in extracellular level of serotonin, neurogenesis, and growth of vessels in the brain. We investigat…

DOI: 10.1038/s41467-024-50220-4