High-Impact Research Publications Using ADInstruments

Evolutionary novelties underlie sound production in baleen whales

DOI: 10.1038/s41586-024-07080-1

Exercise Volume Can Modulate the Regenerative Response to Spinal Cord Injury in Mice

DOI: 10.1089/neur.2024.0023

GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension

BACKGROUND: The precise origin of newly formed ACTA2+ (alpha smooth muscle actin-positive) cells appearing in nonmuscularized vessels in the context of pulmonary hypertension is still debatable although it is believed that they predominantly deriv…

DOI: 10.1161/circresaha.123.323736

Growth/differentiation factor 15 (GDF15) expression in the heart after myocardial infarction and cardioprotective effect of pre-ischemic rGDF15 administration

Abstract Growth/differentiation factor-15 (GDF15) is considered an unfavourable prognostic biomarker for cardiovascular disease in clinical data, while experimental studies suggest it has cardioprotective potential. This study focuses on the direct cardiac ef…

DOI: 10.1038/s41598-024-63880-5

Heart rate variability parameters indicate altered autonomic tone in subjects with COVID-19

Abstract COVID-19 is associated with long-term cardiovascular complications. Heart Rate Variability (HRV), a measure of sympathetic (SNS) and parasympathetic (PNS) control, has been shown to predict COVID-19 outcomes and correlate with disease progression but…

DOI: 10.1038/s41598-024-80918-w

Human olfactory perception embeds fine temporal resolution within a single sniff

DOI: 10.1038/s41562-024-01984-8

In situ assembly of an injectable cardiac stimulator

Abstract Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation dev…

DOI: 10.1038/s41467-024-51111-4

Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension

BACKGROUND: Pulmonary hypertension (PH) is a progressive cardiopulmonary disease with a high mortality rate. Although growing evidence has revealed the importance of dysregulated energetic metabolism in the pathogenesis of PH, the underlying cellu…

DOI: 10.1161/circulationaha.123.067579

Clonal Hematopoiesis of Indeterminate Potential With Loss of <i>Tet2</i> Enhances Risk for Atrial Fibrillation Through <i>Nlrp3</i> Inflammasome Activation

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the risk of myoc…

DOI: 10.1161/circulationaha.123.065597

A common gene signature of the right ventricle in failing rat and human hearts

Abstract The molecular mechanisms of progressive right heart failure are incompletely understood. In this study, we systematically examined transcriptomic changes occurring over months in isolated cardiomyocytes or whole heart tissues from f…

DOI: 10.1038/s44161-024-00485-1