High-Impact Research Publications Using ADInstruments

Vago-splenic signal transduction of cardioprotection in humans

Abstract Background and Aims The spleen serves as an important relay organ that releases cardioprotective factor(s) upon vagal activation during remote ischaemic conditioning (RIC) in rats and pigs. The tra…

DOI: 10.1093/eurheartj/ehae250

VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction

Abstract Alzheimer’s disease (AD) patients exhibit neuropsychiatric symptoms that extend beyond classical cognitive deficits, suggesting involvement of subcortical areas. Here, we investigated the role of midbrain dopamine (DA) neurons in AD…

DOI: 10.1038/s41467-024-53891-1

ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban

BACKGROUND: Intracellular Ca 2+ cycling determines myocardial contraction and relaxation in response to physiological demands. SERCA2a (sarcoplasmic/endoplasmic reticulum Ca 2+…

DOI: 10.1161/circresaha.123.323798

NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload

Background: Mechanical stress on the heart, such as high blood pressure, initiates inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of inflammation and its role in the stressed heart remain unclear. IL-1β (inte…

DOI: 10.1161/circulationaha.122.060860

Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity

DOI: 10.1016/j.neuron.2022.11.015

A brainstem circuit for phonation and volume control in mice

Abstract Mammalian vocalizations are critical for communication and are produced through the process of phonation, in which expiratory muscles force air through the tensed vocal folds of the larynx, which vibrate to prod…

DOI: 10.1038/s41593-023-01478-2

Broadening the clinical spectrum: molecular mechanisms and new phenotypes of <i>ANO3</i>-dystonia

Abstract Anoctamin 3 (ANO3) belongs to a family of transmembrane proteins that form phospholipid scramblases and ion channels. A large number of ANO3 variants were identified as the cause of craniocervical dystonia, but the underlying pathogeni…

DOI: 10.1093/brain/awad412

Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs

Abstract Aims Cardiotoxicity is one major reason why drugs do not enter or are withdrawn from the market. Thus, approaches are required to predict cardiotoxicity with high specificity and sensitivity. Ideal…

DOI: 10.1093/cvr/cvad141

Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin

Abstract Aims Obesity is an epidemic that is a critical contributor to hypertension and other cardiovascular diseases. Current paradigms suggest that endothelial nitric oxide synthase (eNOS/NOS3) in…

DOI: 10.1093/cvr/cvad164

Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening

Abstract Direct modulation of cardiac myosin function has emerged as a therapeutic target for both heart disease and heart failure. However, the development of myosin-based therapeutics has been hampered by the lack of targeted in vitro screening assays. In t…

DOI: 10.1038/s41467-023-43538-y