High-Impact Research Publications Using ADInstruments

SVEP1 is an endogenous ligand for the orphan receptor PEAR1

Abstract Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that causally promotes vascular disease and associates with platelet reactivity in humans. Here, using a human gen…

DOI: 10.1038/s41467-023-36486-0

Targeted Delivery of Apoptotic Cell‐Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation

Abstract The modulation of inflammatory responses plays an important role in the pathobiology of cardiac failure. In a natural healing process, the ingestion of apoptotic cells and their apoptotic bodies by macrophages in a focal lesion result in resolution o…

DOI: 10.1002/adfm.202210864

Ultra‐Histocompatible and Electrophysiological‐Adapted PEDOT‐Based Hydrogels Designed for Cardiac Repair

Abstract Currently, although conducting polymers have exhibited potential electrophysiological modulation, designing bioinspired ultra‐histocompatible conducting polymers remains a long‐standing challenge. Moreover, the water dispersibility,…

DOI: 10.1002/adfm.202211023

Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

Abstract A critical challenge lies in the development of the next‐generation neural interface, in mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradati…

DOI: 10.1002/advs.202300504

Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential

Abstract Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT 2A receptor activation mediates psychedelic effects, prototypical psychedelics activate…

DOI: 10.1038/s41467-023-44016-1

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

DOI: 10.1021/acsnano.2c08110

Injectable tissue prosthesis for instantaneous closed-loop rehabilitation

DOI: 10.1038/s41586-023-06628-x

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy

Abstract Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple organ systems including liver, kidneys and peripheral nerves 1,2 . Although the o…

DOI: 10.1038/s41586-022-05637-6

Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury

Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on electrically triggered CSDs in healthy and brain-injured animals. Rats received eit…

DOI: 10.1126/sciadv.adj2417

Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function

Preservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for donor-recipient match…

DOI: 10.1126/scitranslmed.ade3782