High-Impact Research Publications Using ADInstruments

Induced pluripotent stem cell–derived exosomes attenuate vascular remodelling in pulmonary arterial hypertension by targeting HIF-1α and Runx2

Abstract Aims Pulmonary arterial hypertension (PAH) is characterized by extensive pulmonary arterial remodelling. Although mesenchymal stem cell (MSC)-derived exosomes provide protective effects in PAH, MSC…

DOI: 10.1093/cvr/cvad185

Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma

Dendrite pathology and synaptic loss result in neural circuit dysfunction, a common feature of neurodegenerative diseases. There is a lack of strategies that target dendritic and synaptic regeneration to promote neurorecovery. We show that daily human recombin…

DOI: 10.1126/sciadv.adl5722

Integrating brainstem and cortical functional architectures

Abstract The brainstem is a fundamental component of the central nervous system, yet it is typically excluded from in vivo human brain mapping efforts, precluding a complete understanding of how the brainstem influences cortical function. In…

DOI: 10.1038/s41593-024-01787-0

Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation

Abstract The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG) neurons. However, soma transcriptomes of individual human (h)DRG neurons—critical information to decipher their functions—are lacking due to tec…

DOI: 10.1038/s41593-024-01794-1

Listening to heart sounds through the pressure waveform

DOI: 10.1038/s41598-024-78554-5

LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2

BACKGROUND: Human cardiac long noncoding RNA (lncRNA) profiles in patients with dilated cardiomyopathy (DCM) were previously analyzed, and the long noncoding RNA CHKB (choline kinase beta) divergent transcript (CHKB-DT) levels were found t…

DOI: 10.1161/circresaha.123.323428

Long-lasting forms of plasticity through patterned ultrasound-induced brainwave entrainment

Achieving long-lasting neuronal modulation with low-intensity, low-frequency ultrasound is challenging. Here, we devised theta burst ultrasound stimulation (TBUS) with gamma bursts for brain entrainment and modulation of neuronal plasticity in the mouse motor…

DOI: 10.1126/sciadv.adk3198

Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose

Abstract Vincristine (VCR) is one of the most widely used chemotherapy agents in treating pediatric cancer. Nonetheless, it is known to cause dose-dependent neurotoxicity which can impact virtually every organ system. Despite its widespread…

DOI: 10.1038/s41598-024-65313-9

Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks

Abstract Outcome-guided behavior requires knowledge about the identity of future rewards. Previous work across species has shown that the dopaminergic midbrain responds to violations in expected reward identity and that the lateral orbitofrontal cortex (OFC)…

DOI: 10.1038/s41467-024-45880-1

Evidence for a sustained cerebrovascular response following motor practice

Abstract Motor tasks have been extensively used to probe neuroplasticity and the changes in MRI signals are often associated with changes in performance. Changes in performance have been linked to alterations in resting-state fluctuations of BO…

DOI: 10.1162/imag_a_00282