High-Impact Research Publications Using ADInstruments

Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale

Abstract The advent of neuroimaging has increased our understanding of brain function. While most brain-wide functional imaging modalities exploit neurovascular coupling to map brain activity at millimeter resolutions, the recording of funct…

DOI: 10.1038/s41592-022-01549-5

Generation and comparative analysis of an Itga8-CreERT2 mouse with preferential activity in vascular smooth muscle cells

DOI: 10.1038/s44161-022-00162-1

Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides

Abstract Muscle contraction depends on strictly controlled Ca2+ transients within myocytes. A major player maintaining these transients is the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, SERCA. Activity of SERCA is regulated by binding of micropeptides an…

DOI: 10.1038/s41467-022-31974-1

Open thoracic surgical implantation of cardiac pacemakers in rats

DOI: 10.1038/s41596-022-00770-y

Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice

Abstract Feeding behavior is adaptively regulated by external and internal environment, such that feeding is suppressed when animals experience pain, sickness, or fear. While the lateral parabrachial nucleus (lPB) plays key roles in nociception and stress, ne…

DOI: 10.1038/s41467-022-35634-2

Perirenal adipose afferent nerves sustain pathological high blood pressure in rats

Abstract Hypertension is a pathological condition of persistent high blood pressure (BP) of which the underlying neural mechanisms remain obscure. Here, we show that the afferent nerves in perirenal adipose tissue (PRAT) contribute to mainta…

DOI: 10.1038/s41467-022-30868-6

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function

DOI: 10.1016/j.cmet.2022.07.003

Programmable self-regulated molecular buffers for precise sustained drug delivery

Abstract Unlike artificial nanosystems, biological systems are ideally engineered to respond to their environment. As such, natural molecular buffers ensure precise and quantitative delivery of specific molecules through self-regulated mechanisms based on Le…

DOI: 10.1038/s41467-022-33491-7

Recreating the heart’s helical structure-function relationship with focused rotary jet spinning

Helical alignments within the heart’s musculature have been speculated to be important in achieving physiological pumping efficiencies. Testing this possibility is difficult, however, because it is challenging to reproduce the fine spatial features and complex…

DOI: 10.1126/science.abl6395

Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages

Background: Pulmonary arterial hypertension (PAH) is a type of pulmonary hypertension (PH) characterized by obliterative pulmonary vascular remodeling, resulting in right-sided heart failure. Although the pathogenesis of PAH is not fully understoo…

DOI: 10.1161/circulationaha.122.059435