High-Impact Research Publications Using ADInstruments

Glutamate drives ‘local Ca2+ release’ in cardiac pacemaker cells

Abstract The sinoatrial node (SAN) is the origin of the electrical signals for rhythmic heartbeats in mammals. The spontaneous firing of SAN pacemaker cells (SANPCs) triggers cardiac contraction. ‘Local Ca…

DOI: 10.1038/s41422-022-00693-z

Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts

Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and is characterized by hypertension, inflammation, and placental dysfunction. Gut microbiota plays key roles in inflammation and hypertension. Howev…

DOI: 10.1161/circresaha.122.320771

Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types

DOI: 10.1038/s41587-022-01429-5

In Vitro Matured Human Pluripotent Stem Cell–Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts

Background: Human pluripotent stem cell (hPSC)–derived cardiomyocytes (hPSC-CMs) have tremendous promise for application in cardiac regeneration, but their translational potential is limited by an immature phenotype. We hypothesized that large-sca…

DOI: 10.1161/circulationaha.121.053563

Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure

Abstract Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic inflammation. As elderly populations continue to increase, precision treatments for age-related cardiac decline are urgen…

DOI: 10.1038/s44161-022-00181-y

Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy

Abstract Potassium (K+) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K+channel KCNB1 (Kv2.1) in…

DOI: 10.1038/s41418-022-01072-2

Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing

Itch is a cutaneous sensation that is critical in driving scratching behavior. The long-standing question of whether there are specific neurons for itch modulation inside the brain remains unanswered. Here, we report a subpopulation of itch-specific neurons in…

DOI: 10.1126/sciadv.abn4408

Lean body mass and the cardiovascular system constitute a female-specific relationship

Recent evidence points toward a link between lean body mass (LBM) and cardiovascular capacity in women. This study aimed at determining the sex-specific relationship of LBM with central and peripheral circulatory variables in healthy women and men (…

DOI: 10.1126/scitranslmed.abo2641

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

DOI: 10.1038/s41596-022-00764-w

Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathy

DOI: 10.1172/jci158897