High-Impact Research Publications Using ADInstruments

Non-invasive recording from the human olfactory bulb

Abstract Current non-invasive neuroimaging methods can assess neural activity in all areas of the human brain but the olfactory bulb (OB). The OB has been suggested to fulfill a role comparable to that of V1 and the thalamus in the visual sy…

DOI: 10.1038/s41467-020-14520-9

Phosphodiesterase 3A and Arterial Hypertension

Background: High blood pressure is the primary risk factor for cardiovascular death worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt-resistant essential hypertension and causes death by stroke…

DOI: 10.1161/circulationaha.119.043061

Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration

DOI: 10.1038/s41593-020-0686-7

Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice

DOI: 10.1038/s41593-020-0663-1

Long-term monitoring of intracranial pressure in freely-moving rats; impact of different physiological states

Abstract Background Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. There is limited insight into the regulatory mechanisms of ICP under physiological conditions, and consequent…

DOI: 10.1186/s12987-020-00199-z

Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

Abstract Heart rate is under the precise control of the autonomic nervous system. However, the wiring of peripheral neural circuits that regulate heart rate is poorly understood. Here, we develop a clearing-imaging-analysis pipeline to visua…

DOI: 10.1038/s41467-019-09770-1

Nitrosative stress drives heart failure with preserved ejection fraction

DOI: 10.1038/s41586-019-1100-z

Correction of medication nonadherence results in better seizure outcomes than dose escalation in a novel preclinical epilepsy model of adherence

Summary Objective Medication nonadherence directly contributes to poor seizure control. A lack of emphasis on correcting poor adherence and failures in patient adherence can result in unwarranted alterations to a patient's drug regimen. We have modeled nonad…

DOI: 10.1111/epi.14655

Hypertensive Response to Ischemic Stroke in the Normotensive Wistar Rat

Background and Purpose— Over 80% of ischemic stroke patients show an abrupt increase in arterial blood pressure in the hours and days following ischemic stroke. Whether this poststroke hypertension is beneficial or harmful remains controversial an…

DOI: 10.1161/strokeaha.119.026459

A rat model of complete atrioventricular block recapitulates clinical indices of bradycardia and provides a platform to test disease-modifying therapies

Abstract Complete atrioventricular block (CAVB) is a life-threatening arrhythmia. A small animal model of chronic CAVB that properly reflects clinical indices of bradycardia would accelerate the understanding of disease progression and pathophysiology, and th…

DOI: 10.1038/s41598-019-43300-9