High-Impact Research Publications Using ADInstruments

The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses

RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine production. The zinc finger protein 36 (ZFP36) family genes ( Zfp36 , Zfp36l1 , and Zfp36l2…

DOI: 10.1126/sciimmunol.abo0981

Theory of hierarchically organized neuronal oscillator dynamics that mediate rodent rhythmic whisking

DOI: 10.1016/j.neuron.2022.08.020

Three-dimensional heart extracellular matrix enhances chemically induced direct cardiac reprogramming

Direct cardiac reprogramming has emerged as a promising therapeutic approach for cardiac regeneration. Full chemical reprogramming with small molecules to generate cardiomyocytes may be more amenable than genetic reprogramming for clinical applications as it a…

DOI: 10.1126/sciadv.abn5768

Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

Abstract The intercalated disc (ICD) is a unique membrane structure that is indispensable to normal heart function, yet its structural organization is not completely understood. Previously, we showed that the ICD-bound transmembrane protein 65 (Tmem65) was re…

DOI: 10.1038/s41467-022-33303-y

Touch IoT enabled by wireless self-sensing and haptic-reproducing electronic skin

Tactile sensations are mainly transmitted to each other by physical touch. Wireless touch perception could be a revolution for us to interact with the world. Here, we report a wireless self-sensing and haptic-reproducing electronic skin (e-skin) to realize non…

DOI: 10.1126/sciadv.ade2450

Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics

Abstract Many ultrafast phenomena in biology and physics are fundamental to our scientific understanding but have not yet been visualized owing to the extreme speed and sensitivity requirements in imaging modalities. Two examples are the propagation of passiv…

DOI: 10.1038/s41467-022-33002-8

Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation

Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotyp…

DOI: 10.1126/sciadv.abq7469

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

Abstract The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to…

DOI: 10.1038/s41467-022-31652-2

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization

DOI: 10.1016/j.immuni.2022.05.014

Sodium-calcium exchanger-3 regulates pain “wind-up”: From human psychophysics to spinal mechanisms

DOI: 10.1016/j.neuron.2022.05.017