High-Impact Research Publications Using ADInstruments

Manganese-driven CoQ deficiency

Abstract Overexposure to manganese disrupts cellular energy metabolism across species, but the molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report that excess cellular manganese selectively disrupts coenzyme Q (CoQ) biosynthes…

DOI: 10.1038/s41467-022-33641-x

Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life

Abstract Obesity is a pre-disposing condition for chronic obstructive pulmonary disease, asthma, and pulmonary arterial hypertension. Accumulating evidence suggests that metabolic influences during development can determine chronic lung dise…

DOI: 10.1038/s41467-022-31655-z

Memantine targets glutamate receptors in atrial cardiomyocytes to prevent and treat atrial fibrillation

DOI: 10.1038/s41421-022-00429-8

Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell–endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver o…

DOI: 10.1126/science.abn3027

Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension

DOI: 10.1016/j.immuni.2022.06.018

MicroRNA-dependent suppression of biological pacemaker activity induced by TBX18

DOI: 10.1016/j.xcrm.2022.100871

Modeling human multi-lineage heart field development with pluripotent stem cells

DOI: 10.1016/j.stem.2022.08.007

Molecularly defined circuits for cardiovascular and cardiopulmonary control

DOI: 10.1038/s41586-022-04760-8

The neurons that restore walking after paralysis

Abstract A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the l…

DOI: 10.1038/s41586-022-05385-7

The RalGAPα1–RalA signal module protects cardiac function through regulating calcium homeostasis

Abstract Sarcoplasmic/endoplasmic reticulum calcium ATPase SERCA2 mediates calcium re-uptake from the cytosol into sarcoplasmic reticulum, and its dysfunction is a hallmark of heart failure. Multiple factors have been identified to modulate SERCA2 activity, h…

DOI: 10.1038/s41467-022-31992-z