High-Impact Research Publications Using ADInstruments

Spinal cord injury impairs cardiac function due to impaired bulbospinal sympathetic control

Abstract Spinal cord injury chronically alters cardiac structure and function and is associated with increased odds for cardiovascular disease. Here, we investigate the cardiac consequences of spinal cord injury on the acute-to-chronic continuum, and the cont…

DOI: 10.1038/s41467-022-29066-1

Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

Abstract Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline in experimental genetic models has proven beneficial. Here, we have identified the mechanism of action of…

DOI: 10.1038/s41467-022-31869-1

The cephalic phase of insulin release is modulated by IL-1β

DOI: 10.1016/j.cmet.2022.06.001

The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure

Abstract Failure of the right ventricle plays a critical role in any type of heart failure. However, the mechanism remains unclear, and there is no specific therapy. Here, we show that the right ventricle predominantly e…

DOI: 10.1038/s41467-022-33152-9

The endocannabinoid anandamide is an airway relaxant in health and disease

Abstract Chronic obstructive airway diseases are a global medical burden that is expected to increase in the near future. However, the underlying mechanistic processes are poorly understood so far. Herein, we show that the endocannabinoid anandamide (AEA) ind…

DOI: 10.1038/s41467-022-34327-0

The impact of obesity-related raised intracranial pressure in rodents

Abstract Elevated intracranial pressure (ICP) is observed in many brain disorders. Obesity has been linked to ICP pathogenesis in disorders such as idiopathic intracranial pressure (IIH). We investigated the effect of diet induced obesity (D…

DOI: 10.1038/s41598-022-13181-6

A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses

Abstract Exercise including locomotion requires appropriate autonomic cardiovascular adjustments to meet the metabolic demands of contracting muscles, yet the functional brain architecture underlying these adjustments remains unknown. Here, we demonstrate bra…

DOI: 10.1038/s41467-022-32823-x

Association of incremental pulse wave velocity with cardiometabolic risk factors

Abstract We investigate the association of incremental pulse wave velocity (ΔC; the change in pulse wave velocity over a cardiac cycle) with cardiometabolic risk factors and report the first and (currently) the largest population-level data.…

DOI: 10.1038/s41598-021-94723-2

Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling

Abstract Acute myocardial infarction is a common condition responsible for heart failure and sudden death. Here, we show that following acute myocardial infarction in mice, CD8 + T…

DOI: 10.1038/s41467-021-21737-9

Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

Abstract Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial…

DOI: 10.1038/s41467-021-22788-8