High-Impact Research Publications Using ADInstruments

Loss of CASK Accelerates Heart Failure Development

Rationale: Increased myocardial activity of CaMKII (Ca/calmodulin-dependent kinase II) leads to heart failure and arrhythmias. In Drosophila neurons, interaction of CaMKII with CASK (Ca/CaM-dependent seri…

DOI: 10.1161/circresaha.120.318170

Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension

Background: Exertional intolerance is a limiting and often crippling symptom in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Traditionally the pathogenesis has been attributed to central factors, including ventilation/perfu…

DOI: 10.1161/circulationaha.120.052899

Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart

Background: The failing heart is energy starved with impaired oxidation of long-chain fatty acids (LCFAs) at the level of reduced CPT1 (carnitine palmitoyltransferase 1) activity at the outer mitochondrial membrane. Recent work shows elevated keto…

DOI: 10.1161/circulationaha.120.052671

Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation

DOI: 10.1038/s42255-021-00467-8

Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle

Abstract Zinc, an abundant transition metal, serves as a signalling molecule in several biological systems. Zinc transporters are genetically associated with cardiovascular diseases but the function of zinc in vascular tone regulation is unknown. We found tha…

DOI: 10.1038/s41467-021-23198-6

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

DOI: 10.1038/s41586-020-03180-w

Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin: Bradyarrhythmias, tachycardias, and prolonged interictal QT interval

Abstract Objective To determine electrical changes in the heart in a chronic, nonstatus model of epilepsy. Methods Electrocorticography (ECoG) and electrocardiography (ECG) of nine animals (five made epileptic by intrahippocampal injection of tetanus neuro…

DOI: 10.1111/epi.16479

Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury

Abstract Chronic high-thoracic and cervical spinal cord injury (SCI) results in a complex phenotype of cardiovascular consequences, including impaired left ventricular (LV) contractility. Here, we aim to determine whethe…

DOI: 10.1038/s41467-020-18905-8

Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

Background: High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The im…

DOI: 10.1161/circulationaha.119.043081

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension Via mTORC1 Signaling

Abstract Rationale Vascular remodeling, including smooth muscle cell hypertrophy and proliferation, is the key pathological feature of pulmonary arterial hypertension (PAH). Prostaglandin I2 analogs…

DOI: 10.1164/rccm.201911-2137oc