High-Impact Research Publications Using ADInstruments

Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction

Abstract Oxidative stress plays an important role in the pathogenesis of many disease states. In the heart, reactive oxygen species are linked with cardiac ischemia/reperfusion injury, hypertrophy, and heart failure. While this correlation between ROS and car…

DOI: 10.1038/s41467-018-06533-2

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

Abstract Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing…

DOI: 10.1038/s41467-018-04049-3

Angiotensin II-induced hypertension in rats is only transiently accompanied by lower renal oxygenation

Abstract Activation of the renin-angiotensin system may initiate chronic kidney disease. We hypothesised that renal hypoxia is a consequence of hemodynamic changes induced by angiotensin II and occurs prior to development of severe renal damage. Male Sprague-…

DOI: 10.1038/s41598-018-34211-2

A Magnetic Plethysmograph Probe for Local Pulse Wave Velocity Measurement

DOI: 10.1109/tbcas.2017.2733622

D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels

Abstract Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO 2 and pH homeostasis in the brain. CO 2…

DOI: 10.1038/s41467-017-00960-3

Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission

Abstract Shrm4, a protein expressed only in polarized tissues, is encoded by theKIAA1202gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we rep…

DOI: 10.1038/ncomms14536

Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome

Abstract Patients with short QT syndrome (SQTS) may present with syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding cation channels, explain <25% of SQTS cases. Here we identify a missense mutation in the ani…

DOI: 10.1038/s41467-017-01630-0

Mammalian γ2 AMPK regulates intrinsic heart rate

Abstract AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding ade…

DOI: 10.1038/s41467-017-01342-5

Single-source PPG-based local pulse wave velocity measurement: a potential cuffless blood pressure estimation technique

Abstract Objective: A novel photoplethysmograph probe employing dual photodiodes excited using a single infrared light source was developed for local pulse wave velocity (PWV) measurement. The potenti…

DOI: 10.1088/1361-6579/aa9550

A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

Abstract The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connect…

DOI: 10.1038/ncomms13035