High-Impact Research Publications Using ADInstruments

In Vivo Base Editing of <i>Scn5a</i> Rescues Type 3 Long QT Syndrome in Mice

BACKGROUND: Pathogenic variants in SCN5A can result in long QT syndrome type 3, a life-threatening genetic disease. Adenine base editors can convert targeted A T base pairs to G C base pairs, offering a p…

DOI: 10.1161/circulationaha.123.065624

Blood flows from the SCN toward the OVLT within a new brain vascular portal pathway

The suprachiasmatic nucleus (SCN) sets the phase of oscillation throughout the brain and body. Anatomical evidence reveals a portal system linking the SCN and the organum vasculosum of the lamina terminalis (OVLT), begging the question of the direction of bloo…

DOI: 10.1126/sciadv.adn8350

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pr…

DOI: 10.1126/science.adk8511

Brainstem Dbh+ neurons control allergen-induced airway hyperreactivity

Abstract Exaggerated airway constriction triggered by repeated exposure to allergen, also called hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to function in allergen-induced hyperreac…

DOI: 10.1038/s41586-024-07608-5

Caspase-2 is a condensate-mediated deubiquitinase in protein quality control

DOI: 10.1038/s41556-024-01522-8

Chemogenetics with PSAM4-GlyR decreases excitability and epileptiform activity in epileptic hippocampus

Abstract Despite the availability of new drugs on the clinics in recent years, drug-resistant epilepsy remains an unresolved challenge for healthcare, and one-third of epilepsy patients remain refractory to anti-seizure medications. Gene therapy in…

DOI: 10.1038/s41434-024-00493-7

Chronic acetylcholinesterase inhibition reduces the effects of physical training on ventricular contractility and coronary bed reactivity in hypertensive rats

DOI: 10.1038/s41598-024-69387-3

Control of polymers’ amorphous-crystalline transition enables miniaturization and multifunctional integration for hydrogel bioelectronics

Abstract Soft bioelectronic devices exhibit motion-adaptive properties for neural interfaces to investigate complex neural circuits. Here, we develop a fabrication approach through the control of metamorphic polymers’ amorphous-crystalline t…

DOI: 10.1038/s41467-024-47988-w

CXCL12/CXCR4 pathway as a novel therapeutic target for RNF213-associated pulmonary arterial hypertension

DOI: 10.1038/s41598-024-77388-5

Deciphering the inhibitory effects of trimetazidine on pulmonary hypertension development via decreasing fatty acid oxidation and promoting glucose oxidation

DOI: 10.1038/s41598-024-76100-x